Immunology - 12 Flashcards
The variable region of the light chain and heavy chain make up what?
The antigen binding site
Which are the isotypes of antibodies?
IgG IgA IgM IgE IgD
GAMED
Which isotypes have four domains?
IgM
IgE
(4 ME)
Which isotypes have three domains?
IgG
IgA
IgD
The variable and heavy chains are called the structural regions of the antibody, which are the functional regions?
- Fab
- Fc
- Hinge region
- J-chain
Which region, Fab vs Fc, binds antigen and which one serves as the recognition piece for opsonization by the phagocytes?
Fab - binds antigen
Fc - recognition piece for opsonization by the Fc receptor on phagocytic cells (macrophages and neutrophils)
Which isotypes have a hinged region?
The ones with three constant region domains (G, A, D) the ones with four regions do not (M, E)
What is the J chain?
It is a polypeptide sequence that is needed by some isotypes so they may oligomerize (IgA - dimer, IgM - pentamer) which helps with their function
Is isotype determined by the variable or constant region?
Constant
