IMMUN Respiratory Immunology, Allergy & Host Defences - Week 2

Question 1

Primary phase of an allergic response is driven by what type of cells

Answer 1

Mast cells.

Question 2

Secondary phase of an allergic reaction is determined by what type of cells.

Answer 2

T cells.

Question 3

Function of the respiratory epithelium.

Answer 3

• Mucociliary transport:
• Goblet cells – secreting mucous to trap pathogens
• Cilia – beat in an asymmetric rhythm to move mucus 1cm/min
• Immune function:
• ILC3 & Th17 immune cells @ lamina propria OR BALT
• Secrete IL-22 -> epithelial cell proliferation & barrier integrity.
• Express pattern recognition receptors (e.g., TLRs and NODs), which when activated:
• Secrete chemokines & cytokines at the basal surface -> immune cell recruitment
• Secrete antimicrobial compounds (e.g., defensins) into the lumen

Question 4

Can respiratory cells secrete mucous?

Answer 4

No. They are not goblet cells.