Imaging in inflammatory disorders and infection

Question 1

Molecular imaging

Answer 1

Radionuclide imaging eg PET

Radioactive element and pharmaceutical element

Question 2

PET

Answer 2

Cyclotron produced isotopes with extremely short half lives and emit positrons
Bump particles with oxygen rich water and combine with ligand

Question 3

What does PET show?

Answer 3

Physiological function of organs

Question 4

PET tracer

Answer 4

Gamma emitted by positron - emitting radionuclide

Question 5

FDG

Answer 5

Radiotracer used to show tissues that use glucose

Question 6

Ideal isotope for labelling (5)

Answer 6

• Half life similar to length of examination
• Gamma emitter
• Energy 50-300keV
• Readily available radionuclide
• Easily bound to pharmaceutical component

Question 7

Gamma radiation

Answer 7

Occurs due to radioactive decay of unstable isotope and has a high frequency and energy

Question 8

Gamma camera ENERGY

Answer 8

Nuclear => Gamma => light EM => electrical

nucleus from patient image crystal to display

Question 9

SPECT

Answer 9

CT version of nuclear medicine ( tracer used)

Question 10

What does SPECT look at?

Answer 10

Brain and cardiac studies using roatating gamma cameras

Question 11

What does SPECT show?

Answer 11

Blood flow