Chronic inflammation 1&2 Flashcards
What is the majority of the cell population?
Lymphocytes
Macrophages
Plasma cells
What does chronic inflammation feature?
Loss of function or necrosis
How can chronic inflammation arise?
Follow on from acute inflammation if there is a large amount of damage or can be primary
Healing and repair includes
Granulation tissue
Scarring and fibrosis
Granulation tissue
Patches tissue defects and replaces dead tissue
Contracts and pulls together
Succession of events of organisation
Capillaries => inflammatory mass => access of plasma protein => Macrophage from blood and tissue => fibroblast lay down collagen => Collagen replaces exudate
Products of granulation tissue
Fibrous tissue - scar
Fibrosis - less movement
Can lead to chronic inflammation
Primary chronic inflammation
- Autoimmune disease eg rheumatoid arthritis
- Material resistant to digestion eg mycobacteria
- Exogenous substance - suture, hip replacement
- Endogenous substance - in wrong place eg keratin
What is a plasma cell?
Undifferentiated B cell ==> antibody
b cell presents antigen to Macrophage
What do T cells produce?
Cytokines to attract macrophages
Interferons that are antiviral
Kill cells
NK cells
Destroy antigens and cells
What do macrophages do? (2)
Remove debris
Antigen presentation
What is a macrophage?
A motile phagocyte
Takes over from neutrophils
Contains enzyme eg lysosome and can produce interferon
Fibroblasts are…
Motile
Make collagen
Metabolically active
Granulomatous infection
Granuloma in tissues and cause serious infection
Aggregation if macrophage in epithelium cells and look like epithelium
