IIIR3a Flashcards
What is the dominant cell in most chronic inflammation?
Macrophages.
Type I allergic rxns typically occur via what immune response?
IgE-mediated reactions.
Type II allergice rxns typically occur via what immune response?
Small molecules bind to self cell body, making it perceived as “foreign” by immune system. B-cells make IgG, complement system gets involved and phagocytosis.
What are the trades of Type III allergic rxns?
Foreign soluble proteins bind to IgG and it complexes. Then lodges in alveoli or vessels. Complement gets involved.
What are the trades of Type IV allergic rxns?
Caused by CD4Th1 cells (a minority caused by CD8 cells). Lipid soluble molecules crosses PM, binds to protein, then weird peptides made when it is degraded. Delayed onset (1-3 days after exposure).
What is a prerequisite for Type I sensitivity?
IgE antibody is made when a person first encounters theA Ag.
How does IgE bind to cells?
via FCepsilonRI, and it is a very tight association.
What makes a mast cell degranulate?
Cross-linking of FCepsilonRI.
What is the function of histamine and heparin?
- toxic to parasites
- increase vascular permeability
- smooth muscle contraction
What does TNFalpha do?
- promotes inflammation
- stimulates cytokine production
- activates endothelium
What do Tryptase, chymase, cathepsin G and carboxypeptidase to?
remodel connective tissue matrix.
What does IL-4 and IL-13 do?
increases Th2 cell response
What does IL-3, IL-5 and GM-CSF do?
eosinophil activation and production
What does TNF-alpha do?
promotes inflammation, causes cytokine production, activates endothelium
What does CCL3 do?
chemotactic for monocytes, macrophages and neutrophils
What do leukotrienes C4, D4 and E4 do?
smooth muscle contraction, increase vascular permeability, mucus secretion
What does PAF do?
chemotactic for leukocytes, amplifies production of lipid mediators, activates neutrophils, eosinophils and platelets.