III - Connective Tissue Flashcards
Connective Tissue: Cells
fibroblasts, mast cells, plasma cells, adipocytes, monocytes, macrophages, leukocytes
Connective Tissue: Fibers
collagen, reticular, elastic
Connective Tissue: Ground Substance
glycosaminoglycans (GAGs), proteoglycans, multiadhesive glycoproteins
Connective Tissue: adipose
loose/areolar
Connective Tissue: palms, soles, buttocks
adipose (loose/areolar)
Connective Tissue: reticular
loose/areolar
Connective Tissue: liver, bone marrow, pancreas, adrenal glands, all lymphoid organs except thymus
reticular (loose/areolar)
Connective Tissue: dermis, submucosa of digestive tract, organ capsules
dense irregular
Connective Tissue: muscles, ligaments, tendon, aponeuroses, corneal stroma
dense regular
Specialized Connective Tissue
cartilage, bone, blood, lymph
Most abundant protein in the body
collagen
AA that appears in collagen at every third position in the alpha chain
glycine
Collagen: basal lamina
IV
Collagen: reticular fibers
III
Collagen: bone
I
Collagen: most cartilage
II
Collagen: tendon
I
Collagen: keloid
III
Collagen: granulation tissue
III
Collagen: old scar
I
Collagen: most ubiquitous, most abundant
I
Collagen: tunica media of blood vessels
III
Collagen: dermis
I
Collagen: fibrocartilage
I
Collagen: organic parts of bones and teeth
I
Collagen: hyaline cartilage (50% of all cartilage)
II
Collagen: elastic cartilage
II
Collagen: vitreous humour
II
Collagen: early part of wound healing
III
Collagen: visceral and hollow organs
III
Collagen: lens capsule
IV
Vitamin responsible for hydroxylation of collagen
vitamin C
Type I Collagen Deficiency
Osteogenesis Imperfecta
Type IV Collagen Deficiency
Alport’s Syndrome
Differential for Alport’s Syndrome
Goodpasture’s Syndrome
Cartilage: smooth surface for easy movement
hyaline
Cartilage: bronchial tubes, larynx, costal cartilage, articular surfaces of bone
hyaline
Cartilage: support, flexibility, shape
elastic
Cartilage: auditory tube, external ear, epiglottis
elastic
Cartilage: shock absorber, deepens bone sockets
fibrocartilage
Cartilage: intervertebral disks, menisci of knees, around articular cavities, callus, pubic symphisis, portions of tendons
fibrocartilage
Cartilage: bluish-white, semi-transparent, type II collagen, aggrecan, chondrocytes
hyaline
Hyaline: Perichondrium is present except at
epiphyses, articular cartilage
Cartilage: similar to hyaline, yellowish, perichondrium
elastic
Cartilage: chondrocytes scattered among thick interlace of collagen fibers, no perichondrium
fibrocartilage
Cartilage: results from mitotic division of preexisting chondroblasts
interstitial growth
Cartilage: differentiation of new chondroblasts from the perichondrium
appositional growth
Cartilage: Ground Substance
chondroitin sulfate, keratan sulfate, chondronectin, chondrocalcin
Cartilage: Mineralization
none
Cartilage: Hydration
75%
Cartilage: Collagen
I - fibrocartilage, II - hyaline & elastic
Cartilage: Vascularity
avascular (nutrient diffusion)
Cartilage: Nerves
absent
Cartilage: Growth
interstitial, appositional
Cartilage: Repair
low
Cartilage: Mitosis
chondrogenic (chondroblasts, chondrocytes)
Cartilage: Gap Junction
none
Cartilage: Hormonal Influence
present
Cartilage: Vitamin Influence
none
Bone: Ground Substance
chondroitin sulfate, keratan sulfate, osteonectin, osteocalcin, osteoporin
Bone: Mineralization
hydroxyapatite, citrate, bicarbonate
Bone: Hydration
7%
Bone: Collagen
I - tensile strength
Bone: Vascularity
highly vascular
Bone: Nerves
present
Bone: Growth
intramembranous, endochondral
Bone: Repair
high
Bone: Mitosis
osteoprogenitor cells
Bone: Gap Junction
present
Bone: Hormonal Influence
present
Bone: Vitamin Influence
present
Avascular necrosis commonly affects
femoral head