Igra , Cryptic Tb, Miliary Tb , Primary Tb Flashcards
IGRA moa and antigens used
Detect ifn gamma against tubercular Ag
Esat-6 , cfp-10 ,tb7.7
Types of igra
Tb quantiferon gold - elisa
Spot tb assay- 6 and 10 used - by elispot
Advantages
Less fp
Atypical doesnt affect
Once
Advantages of igra over tst
No cross reactivity with ntm
No boosting phenomena
No potential for conversion
Results early
Classification of tb based on sequence of events
Location
Primary- disease caused by tb in person with no previous exposure
Progressive- when primary is not contained n progress to disease
Localized- pulm / extra pulm
Disseminated
When do u call disseminated
2 non contigous sites
Millet size lesions
How many stages in wallfreb timetable of tb and significance
5 stages
Predict manifestations of tb in children
What is granuloma
Focal , compact collection of inflammatory cells in which mononuclear cells predominate
Result of persistent non degradable product or reult of hsn or both
What are the new tests available
Next generation sequencing - figure out order id dna nucleotidesor bases in a genome
Ghon focus
Complex
Seen in
Seen in primary tb
Bacilli reaches alveoli. Lower part of upper lobe or upper part of lower lobe
గ్రే white inflammation- focus- subpleural
Complex - focus+ lymohangitis+lymphadenitis
Rhankes complex
Calcified complex is ranke complex
What are the lesions which can be seen in post primary tb in lung
Bronchus
Pleura
Lobar
Nodular
Cavity
Broncho pneumonia.
Bronchial: inflammation , endobronchial, ectasis
What are the complications of cavity
Hemoptysis
Aspergilloma
Amyloidosis
Carcinoma
Pathology of miliary tb
Small ,punctuate , గ్రే to reddish brown roynded lesions of equal size
Risk factors of miliary tb
Spread
Extrenes of age ,
Ic
Is
Silicosis
