Att Induced Hepatitis Flashcards
1
Q
Drugs causing hepatotoxicity
A
H+r H Z R Eto Pas Bdq Fq
2
Q
Pathology
A
Direct injury Cholestasis due to gebetic defect in transporter Haptens formation Ab dependant cytotoxicity Mitochondrial damage Metabolic mediated
3
Q
Moa R Z Pas/fq Pro/eto Inh
A
Inhibit major bilesalt export pump Idiosyncratic hepatotoxic Hsn Unknown Direct/metabolic mediated
4
Q
Went to stop ATT in case of hepatitoxity
A
Enzymes 3 times over upper limit in case of Jaundice
enzymes 5 times of upper limit in options of symptoms
Any increase in serum bilirubin
5
Q
How do you manage ATT induced hepatotoxicity
A
Stop all ATT
if severely ill -SLE
6
Q
When do you restart att
A
When the symptoms resolved and enzymes less than two times
7
Q
Sequence if restarting
A
RHZ
8
Q
Regimen if cant be given
Rz
H
Z
A
Rz- hes 2 , 10 he
H- rze 6-9
Z- HRE 9
9
Q
Regimen in liver disease
A
Sle 12 months
Or 3sle f/b 9le
