Drug Resistnance Mechanism Flashcards
1
Q
Mechanism
A
Primary- already resistant organism 2- acquired- dose or non adherence Previous rx- inadequate/incomplete rx Single drug/ add/ ipt inapp Lack of gud labs Virulence of organism Host genetoc factors
2
Q
Inh
A
Kat g
Inh a
Acp
Oxy r - oxydative stress regulator
3
Q
Rif
A
Rpob
4
Q
Pzide
A
Pnc a
Pyrazinamidase
5
Q
Ethambutol
A
Arabinosyl transferase
Emb a,b, c
6
Q
Capreomycin
A
Hemolysin
7
Q
Fq
A
Gyr a b
8
Q
Streptomycin
A
16s ribosoml rna
Str a
9
Q
Ethionamide
A
Inh a
Eth a
10
Q
Pas
A
Thy a
11
Q
Linezolid
A
23 sr rna
12
Q
Clofazamine
A
Efflux pump related gene
13
Q
Bedaquiline
A
Efflux pump related gene
14
Q
Delamanid
A
Mutation in f420
