ID 5 - Abx resistance

Question 1

Bacteria causing liver abscess unresponsive to ABX and drainage + “sticky” cultures on 🧫

Answer 1

Hypermucoviscous Klebsiella (aka hypervirulent)

Question 2

Why is Clindamycin especially good for Clostridium Tx?

Answer 2

Inhibits toxin production

Question 3

Does Pseudomonas typically cause endocarditis?

Answer 3

no (doesn’t have capacity for endothelial adhesion)

Question 4

2 organisms that typically cause small renal abscesses

Answer 4

S. aureus and Candida

Question 5

Does tazobactam have activity against carbapenemases?

Answer 5

no

Question 6

Do carbapenem-resistant strains of Pseudomonas typically produce carbapenemases?

Answer 6

no

Question 7

2 major mechanisms of carbapenem resistance in Pseudomonas

Answer 7

loss of porins; efflux pumps

Question 8

2 carbapenemase inhibitors

Answer 8

avibactam; vaborbactam

Question 9

Aminoglycosides have poor _____ penetration.

Answer 9

lung

Question 10

Is Pseudomonas lactose fermenting?

Answer 10

no

Question 11

Is Klebsiella lactose fermenting?

Answer 11

yes