Heme/Onc 4 - immune thrombocytopenias

Question 1

Hypertension, AKI, thrombocytopenia, MAHA, PH, and neurologic dysfunction after recent stem cell transplant

Answer 1

Transplant-associated thrombotic microangiopathy

Question 2

Does transplant-associated TMA respond to stopping the drug and steroids?

Answer 2

No

Question 3

Fever, rash, Pulm edema, and organ dysfunction after recent stem cell transplant

Answer 3

Engraftment syndrome

Question 4

Coagulation factor made largely outside of liver

Answer 4

Factor VIII

Question 5

Which doesn’t have schistocytes: ITP, TTP, or DIC?

Answer 5

ITP

Question 6

Tx for cytokine release syndrome from CAR-T treatment

Answer 6

Tocilizumab

Question 7

Target of tocilizumab

Answer 7

IL-6

Question 8

Preferred med for tumor lysis syndrome

Answer 8

rasburicase

Question 9

Tx for refractory TTP (4)

Answer 9

PLEX, steroids, rituximab, and caplacizumab

Question 10

target of caplacizumab

Answer 10

vWF

Question 11

Vaccine-induced immune thrombotic thrombocytopenia (VITT) and HIT both involve Abs targeting _____.

Answer 11

anti-platelet factor 4

Question 12

Initial Tx for VITT (2 components)

Answer 12

AC and IVIg