ID 2 - Carbapenem Resistance

Question 1

Staph lugdunensis (a coag - staph) bacteremia should be treated similarly to this other organism.

Answer 1

S. aureus

Question 2

In addition to Abx, treatment for Staph lugdunensis bacteremia should include _____ and _____.

Answer 2

removal of indwelling catheters; TEE

Question 3

Antibiotic that is stable against all 3 forms of beta-lactam resistance in PsA

Answer 3

Ceftolazone-tazobactam

Question 4

3 classic mechanisms of Gram-negative carbapenem resistance

Answer 4

Inactivation (by β-lactamases), impermeability, and efflux

Question 5

Entry point for most β-lactams through the bacterial cell wall

Answer 5

Porin channels

Question 6

2 Abx stable against β-lactamases, porin closure, and efflux

Answer 6

Cephiderocol and ceftolazone-tazobactam

Question 7

Difference in carbapenemase resistance between ceftolozane-tazobactam and cephiderocol

Answer 7

Ceftolozane-tazobactam is not resistant to serine- and metallo-carbapenemases

Question 8

Where are serine carbapenemases (KPC, OXA) predominant?

Answer 8

East Asia, Europe, and the Americas

Question 9

Where are metallo-carbapenemases (NDM) predominant?

Answer 9

South Asia (NDM = New Delhi metallo-β-lactamase)

Question 10

Is meropenem-vaborbactam effective in carbapenem resistant PsA?

Answer 10

No.