IBS + constipation Flashcards
What causes IBS
Unknown cause related to gut sensitivity and altered motility
No inflammation or damage to bowel
What brings IBS on
Stress Anxiety Depression Emotional distress Menstruation Gastroenteritis
What are the S+S of IBS
Rome Criteria Abdominal pain +2 of Relief by defaecation Altered frequency Altered form - Constipation or Diarrhoea >6 months
Other 2/4 Urgency / straining Incomplete evacuation Bloating Worse by eating Mucous / bleeding in stool
What is characteristic of IBS abdominal pain
Radiate to back Vague Burning Altered by bowel action Rare at night Non-cyclical (endometriosis can mimiic)
What are other features
Lethargy
Nausea
Backache
Bladder issues
What investigations do you perform in IBS
Clinial with Rome criteria if no red flag
Bloods - FBC, ESR, CRP, coeliac if classic Hx to exclude +- calprotectin + stool culture (in GP)
VE and abdo exam
Urea breath test
Colonoscopy if 60+ / alarm symptoms
Refer if FH ovarian / bowel
Consider clinical context but don't do regularly Thyroid Coeliac serology Ca-125 Stool culture Calprotectin Rectal examination FOB B12 deficiency Hydrogen breath
What is calproctectin
Marker of inflammation in mucosa
Detects neutrophils in the stool
Differentiates IBD and IBS
How do you treat IBS non-pharmacological
Dietic review - FODMAP, lactose, gluten
Exercise
Reduce stress
Psychotherapy if refractory >12 months
How do you treat pain in IBS
Anti-sposmodics - Buscopan for colicky pain
Antidepressants - TCA 2nd line or SSRI (also if refractory)
How do you treat bloating
Probiotics
Avoid fibre and bulking agents
How do you treat constipation
Laxatives
- 5HT4
Avoid FODMAP
Water + fibre
How do you treat diarrhoea
Anti-motility agent - loperamide = 1st line
FODMAP
Avoid caffeine / alcohol
What are alarm symptoms in IBS requiring colonoscopy
50+ as unlikely to have IBS Short history <6 months Recent change in bowel habit Weight loss Nocturnal symptoms Male FH Bowel / ovarian ca / IBD Mouth ulcers Anaemia Abnormal CRP Rectal bleeding Abdominal mass or LN \+e FOB Recent antibiotic use as decreased diversity
What drugs cause constipation
Opiates Anti-cholinergic Iron Diuretic CCB
What are neurogenic causes of constipation
Neuropathy Parkinson's Stroke MS Spinal cord injury Systemic sclerosis
What are organic causes
Strictures Malignancy Diverticulitis IBD Fissure Prolapse Obstruction Psuedo-obstruction after operation Gastrostasis due to DM Hisprung;s
What are systemic causes of constipation
Diabetes
Low thyroid
Hyper-calcium
Hypokalaeimia
What are functional causes of constipation
Mega colon Depression Psychosis Pain No toilet
What are other causes of constipatio
Lack of fibre Lack of exercise Unhealthy BMI Dehydrated Age Hospital / post-op
How do you Dx constipation
DRE to look for impaction Bowel sounds Abdo exam FBC, ESR, U+E, Ca, TFT Colonoscopy if suspected malignancy