Hyper 4

Question 1

Type 4 H/S rxns are ___-____, like the late phase of type 1 H/S rxns (excema)

Answer 1

cell-mediated

Question 2

two main types of DTH rxns? what do they each cause?

Answer 2

1) contact h/s (poison ivy, etc)–> BLISTER

2) Tuberculin-type H/S –> INDURATION/hardness

Question 3

acute inflammation: initial Vconstrict, then Vdilate –> which two molecules released cause the Vdilation??

Answer 3

prostacyclin, nitric oxide

• result in redness (rubor), heat (calor)
• ALSO will cause constriction afterward and allow plasma to leak thru - blood flow SLOWS b/c fluid is lost

Question 4

selectins are slinkies that mediate t___ as the leukocyte rolls along the endothelial cell wall

• E-selectin (aka ELAM-1) binds what?
• L-selectin binds what?

Answer 4

tethering - slows it down!
E-selectin (aka ELAM-1) binds GLYCOPROTEIN on the leukocyte
-L-selectin (on LEUKO) binds CD34 on endo

Question 5

chemokines, especially IL-__, ACTIVATE the leukocyte to prep it from transmigration across the endo cell wall

Answer 5

IL-8

Question 6

Integrins provide the firm ____ to the endo cell: what molecule on the LLLeukocyte binds what molecule on the endo cell?

Answer 6

adhesion

-LFA-1 (on Leukocyte) binds ICAM-1 on endo cell - facilitates transmigration

Question 7

What does PECAM do? T/F: PECAM can work before integrin binding

Answer 7

FALSE! Needs integrin first; PECAM is the initiator of transmigration

Question 8

What’s the final effector cell in DTH rxns?

Answer 8

the MACROPHAGE!

Question 9

which three adhesion molecules involved in WBC binding endothelial cell wall?

Answer 9

selectins (E,P,L) - the spring trap

chemokines (IL-8) - the leukocyte activator integrins - firm adhesion