AIDS

Question 1

congenital COMBINED (B and T cell) deficiency: \_\_\_\_
-causes a deficiency in \_\_\_ and results in accumulation of t\_\_\_ metabolites

Answer 1

SCID - severe combined immunodef.

• ADA: adenosine deaminase (b/d adenosine)
• can’t break it down.
• TOXIC metabolites - lymphocyte infection

Question 2

AIDS: reduction in WHAT type of cell by __% or more

Answer 2

T-helper by 20% or more

Question 3

AIDS has killed:

• world: ___, still alive: ___
• US: ___, still alive: ___

Answer 3

39, 35

600K, 1.1 mil dead

Question 4

T/F: tears can trigger HIV

Answer 4

FALSE! but needles, sex and babies can

Question 5

which protein is used by HIV to downregulate the host’s class 1 MHCs (CD4s)

Answer 5

nef-protein

Question 6

most commonly ocular-observed AIDS finding:

• second most common observance?
• another ocular finding caused by a fungal infection of the lungs?

Answer 6

CWS
-CMV retinitis

-pneumocystis carinii

Question 7

name the three components of HIV: what’s contained in each?

Answer 7

outer matrix
inner capsid - reverse transcriptase, integrase, protease
envelope - gp41 and gp120

Question 8

what two components are REQUIRED for infection to occur on the T-cell? [CC]
-which is initially bound by gp120?

Answer 8

CD4 - bound by gp120 to ALLOW binding to the:

Chemokine receptor…at which point, conf change from gp120–>gp41 occurs and insertion is possible

Question 9

what are two classes of drugs used to treat HIV?

Answer 9

RTIs - reverse transcriptase inhibitors - AZT (Truvada)

Protease inhibitors - BIG ONE!! - block packaging/export

Question 10

what ocular condition can result as a consequence of HAART therapy?

Answer 10

immune recovery uveitis = vitritis + CME (post. seg complications)