Hyper 2

Question 1

main thing type II H/S rxns deal with? Esp which two?

Answer 1

antibodies! IgG and IgM

-both made/sent out to resist cell/tissue antigens

Question 2

four main mechanisms of antibody-mediated cell immunity?

Answer 2

1) Complement-mediated cell lysis
2) Phagocytosis of opsonized cell
3) Complement-dependent recruitment/inflammation
4) Fc-receptor mediated recruitment/inflammation

Question 3

three main examples of complement-mediated cell lysis?

Answer 3

• Transfusion rxns
• hemolytic disease of newborn
• hyperacute graft rejection

Question 4

complement-mediated cell lysis uses what as its main elimination mechanism?

Answer 4

similar to classical pathway: C5-C9 to eventually punch holes and cause osmotic lysis

Question 5

Phagocytosis of opsonized cell: what acts as the opsonizer? Two main molecules involved here?

Answer 5

antibodies!

C3b; Fc receptor

Question 6

Complement-dependent recruitment/inflammation: uses mainly which protein? What are two ocular manifestations?

Answer 6

C5a: chemotactic protein - object too big; cell explodes intentionally

• cicatricial pemphigoid: conjunctival fibrosis
• mooren’s ulcer: antibodies in corneal EPI and STROMA

Question 7

Fc-receptor mediated recruitment/inflammation: two main players here: [both begin w/ N]

Answer 7

NK cells, neutrophils: both attract ROS and enzymes to produce more injury/inflamm

Question 8

Fc-receptor mediated recruitment/inflammation: main mechanism? A___C

Answer 8

ADCC - antibody-dependent cell cyto? toxicity

-Causes NK cells to release perforin/granzyme to trigger apoptosis of infected cells - GOITER in thyroid