HUS

Question 1

Symptoms of HUS

Answer 1

Nausea, diarrhoea, anorexia, abdominal pain, weaknrss, oligouria, oedema, pyrexia, hypertension, tachycardia

Question 2

What causes HUS?

Answer 2

E. coli 0157 & Shigella - shigatoxin

Question 3

What might lab findings show?

Answer 3

High creatinine, high urea, proteinuria, haemolytic anaemia

Question 4

What might a HUS blood film show?

Answer 4

Schistocytes, microspherocytes, thrombocytopenia, reactive neutrophilia

Question 5

What does shiga toxin do?

Answer 5

damage intestinal epithelium and gain access to vascular system, bind to endothelial cells causing apoptosis, necrosis, induce inflammation and activate platelets. cause thrombotic microangiopathy - TMA causes macroangiopathic haemolytic anaemia sue to RBC fragmentation causing mechanical trauma

Question 6

Why does it affect kidneys?

Answer 6

Toxin receptors on glomerular endothelial cells

Question 7

Treatment of HUS?

Answer 7

RBC & PLT transfusion & rehydration therapy

Question 8

Are antibiotics use to treat HUS?

Answer 8

No they can worsen symptoms - used if risk of sepsis

Question 9

Is this acute or chronic kidney disease?

Answer 9

acute - 10% develop chronic - 25% have long-term damage