Cardiovascular Disease Flashcards
What is the cardiovascular system?
~Responsible for delivering blood to different parts of the body
~organs & tissues
~Heart (muscular pump forces blood around body)
~Closed system of blood vessels
What is the vena cava?
~inferior vena cava brings deoxygenated blood from the lower half of the body to the right atrium
~Superior brings deoxygenated blood from to top half of the body to the heart
What is the aorta?
Largest artery - connects left ventricle of the heart to all body tissues (except lungs)
What is the carotid artery?
In neck - brings blood to brain and head
What is a thrombus and what risks factors are associated with it?
~intravascular (within peripheral blood stream) blood clot
Risks include
1 - slow blood flow e.g. hypotension, CHD, long air flights
2- damages the smooth intimal lining of the blood vessels - cholesterol, ketoacidosis, diabetes
3- increased blood coagulation - thrombocytosis
What risk factors are associated with blood coagulation?
~some malignant diseases & disorders of blood clotting
~pregnancy - increased blood production
~childbirth
~Oral contraceptives (oestrogen) “The Pill”
~use of tampons & moon cups - blood held in vaginal cavity
~standing for long periods of time e.g. cashiers
What is deep vein thrombosis?
~usually occurs in the veins of the lower limb e.g. pelvic & iliac regions
~Pain & swelling - tends to be asymptomatic in deeper veins
What is an embolus?
~Mass of any material being carried by the blood
~Most Common - fragment of a thrombus - deep vein thrombus - may cause pulmonary embolism (piece of thrombus carried via blood vessels to lungs)
What material can be emboli?
~Pieces of thrombi
~Amniotic fluid emboli
~Tumour fragments - may cause metastases
~Nitrogen bubbles in decompression sickness (bends)
~Fragments of atheromatous plaques
Air emboli - puncture of blood vessel by broken rib, phlebotomy, surgery
What is an embolism?
~Travelling embolus lodges and obstructs a blood vessel
~Pulmonary embolism in lungs, blockage of coronary arteries - myocardial infarction, blockage of cerebral artery - cerebral infarction
What is infarction?
Tissue death due to interrupted blood supply - may result in amputation
What is ischaemia?
Tissue damage due to reduced blood flow - angioplasty to get rid of obstruction
What is shock?
~Metabolic needs of a cell are not met due to inadequate blood flow
~Caused by reduction in circulating blood volume, blood pressure, & cardiac output
~Causes hypoxia - inadequate supply of nutrients & accumulation of waste products
~ causes pale skin. weak but rapid pulse, irritability, thirst, irregular heart beat, dizziness, sweating
What is hypovolaemic shock?
~Blood volume falls by 15-25% - reduced cardiac output
~caused by severe burning (plasma lost), haemorrhages, emesis & diarrhoea (water & electrolytes lost)
What is cardiogenic shock?
~Acute heart disease - damage to muscle can’t maintain adequate cardiac output
~Inadequate blood flow to tissue e.g. myocardial infarction
What is septic shock?
~Bacteraemic endotoxin - bacterial endotoxin in blood - massive inflammatory & immune response - powerful mediators released
~Hypotension - widespread vasodilation, depression of myocardial contractibility, poor tissue perfusion. & tissue death
~Multiple organ dysfunction