Humoral Immune 2- Part 1 Flashcards
Naive B lymphocytes express 2 classes of antibodies:
Ig _ and _
M and D
Repeated exposure to an antigen results in the production of antibodies with increased affinity = _______ maturation
Affinity
When antigens fit properly within an antibody-binding site, the max number of interactions can occur between the 2, generating the highest ______
Affinity
What do BCRs express that together will bind to fragments of complement proteins and deliver an additional signal to the B cell nucleus?
B cell co-receptors
Mature B cells travel to the lymph node via the blood stream and leave via _________ lymph if they fail to find the appropriate Th cell inside a lymph
Efferent
B cells and Th cells enter lymph nodes through ____ and interact to effect B cell activation
HEVs
What are the specialized venues inside of lymph nodes and Peyer’s patches that have receptors for cell-surface proteins on T and B cells?
HEVs
How do BCRs internalize the antigen-antibody complexes?
Receptor-mediated endocytosis
Newly formed endosomes fuse with lysosomes that contain proteolytic enzymes and MHC class __ molecules
2
Some B cells that encounter antigen ________ to the primary lymphoid follicles in which the germinal center forms
Migrate
What are dividing B cells called?
Centroblasts
What are resting B cells called?
Centrocytes
Germinal centers contain ___ cells and follicular DC
Th
_______ cells leave via the efferent lymphatics
Plasma
In germinal center, B cells undergo Isotypes switching, and somatic ___________, then emigrate to the lymph nodes and differentiate into plasmas cells
Hypermutation
