Cellular Immune 1- Part 4 Flashcards
Superantigens ___ ____ require MHC antigen presentation
DO NOT
Superantigen only binds to the __ chain
Beta
What 2 cytokines are more associated with toxic shock syndrome
TNF-alpha
IL-1
What antigens have the following charactersits:
Powerful T cell response
High cytokine production
Toxic shock syndrome
Superantigen
CD4 helper T cells subpopulations are distinguished by _________ production
Cytokine
CD4 Helper _ T cell (Th_) is associated with cellular immune response
1
Th1 cells produces IL-_ and IFN- _
2
Y
IL-_ activates T cells, B cells, NK cells, and macrophages
2
IFN-_ inhibits Th2 cells, stimulates Th1 cells, activates NK cells and macrophages
Y
What type of APC and MHC class is presenting Th1 cells for cellular immune response ?
Endogenous APC
MHC class 1
IL-2 promotes Th1 activation = _ cell growth and differentiation
T
IL-2 can promote B cell proliferation, but only ______ cells
Activated
/ T cells may act as ______ immune cells with an invariant antigen receptor, others might be classic helper T cells with diverse TCRs of polyclonal origin
Gamma/delta
Innate
What T cells have the following characteristics when in the innate immunity:
Found in skin and uterus
Limited TCR diversity recognizing CD1d-associated-lipids
Produce IFN- y and IL-17
AP to alpha/beta T cells
Gamma/delta
What T cells have the following characteristics when in the Adaptive immunity:
Found in GI tract and 2nd lymphoid organs
Polyclonal TCRs recognizing multiple antigens
Th1 subset IFN- y and IL-4
Gamma/delta
