Cellular Immune 2- Part 2 Flashcards
The outer ring of adhesive proteins of the immunological synapses forms an effective “________” that prevents leakage of cytotoxic molecules into tissue fluid
Gasket
The two central SMACs have the function of:
1) ___________ and contains the TCR together with accessory molecules and co-stimulators
2) ___________ mechanisms
Signaling
Cytotoxic
It is through ______ that performing, granzymes, and Fas-FasL signals are transmitted
cSMAC
Intrinsic Pathway- Lethal hit of Cytotoxic T cell
Signal goes from:
MHC 1 to TCR —> granules —> granzymes —> perforins —> caspase-3 —> DNA fragments —> __________
Apoptosis
Extrinsic Pathway- CD95L- Cytotoxic cell response:
MHC 1 to TCR —> CD95-L —> CD95 —> Caspase-8 activation —> Caspase-3 activation —> DNA fragmentation = _________
Apoptosis
In the second step of CD8 + T cell mediated cytotoxicity:
The Fas and Fas-L
MHC 1 and CD8
ALL _______
Bind
What is result of the CD8 + T cell mediated cytotoxicity?
Release of lytic granules into the target cell
The CD8 + T cell mediated cytoxoxity by the release of lytic granules is _________ pathway
Intrinsic
Both of the intrinsic and extrinsic pathways lead to ______ activation, DNA fragmentation, and cell death
Caspase
Extrinsic pathway is activates by the ligation of death receptors such as CD__ and formation of the death-inducing signaling complex (DISC)
95
The intrinsic pathway is initiated by multiple damage signals, including injection of granzymes, and leads to the release of cytochrome C from mitochondria, the formation of an apoptosome, and activation of caspase _
9
What are the 2 targets of the mechanisms of cell cytotoxicity?
Tumor cells
Or
Virus-infected cells
Cytotoxic T cell mechanisms is MHC ________
Restricted
Cytotoxic T cell mechanisms is mediated by _______ and _______
Perforins
Granzymes
Macrophages, neutrophils, and NK mechanisms are ____ MHC restricted
NOT
