Cellular Immune 1- Part 3 Flashcards
FIRST:
CD154-CD __
40
SECOND:
CD28-CD__
CD28-CD87 with _ cells
80
B
What is the function of the following:
CD28-80
CD28-86 B cells
Activation of T cells or APC
What IL- _ cells up regulate survival genes, increase energy metabolism and promotes T cell division?
IL-2 T cells
CD152-80/86= T cell ___________
Suppression
What is the following:
Production of Indoleamine dioxygenase - destroys tryptophan
T cell suppression
T cell suppression: (CD152-80/86)
Absence of tryptophan = T cells cannot respond to antigen = T cell response is __________
Terminated
After binding to an antigen the TCR causes the T cell to _______ CD40 ligand
Express
Dendritic cells and macrophages are stimulated through TLR2 secrete IL-__
23
Th0 differentiate into Th__ cell
17
Th0 with IL-6 and IL-23 and transforming growth factor beta= Th__
17
Th17 —> IL-__
17
IL-__ = neutrophil accumulation and activation = promotes __________
17
Inflammation
Interaction between APC and T cells generates a supramolecular structure = ___________ synapse
Immunological
What has the main function of gene expression = proteins?
Transcription factors:
Nuclear factor kB, activated T cells
Activator protein-1
Stimulation of T cells require, _______ signals
Multiple
How many MHC 1 molecules + antigens are required to activate 1 CD8 T cell?
1
How many MHC 2 + antigens are required to activate 1 CD4 T cell molecule
1000
With NO or WITH CD28= 8000 MHC + antigens = _____ TCR
8000
Only antigen + 1 TCR= _____ signal
Multiple antigens and TCR= ______ strong
Weak strong
With costimulation and LESS antigen = ______ signal
Strong
