Cellular Immune 2- Part 3

Question 1

Macrophage activation by the cellular immune response:
____ —> IL-12 and IFN-y
___ —> IL-2 and IFN-y

Answer 1

APC
Th1

Question 2

Normal __________ are killed by growing intracellular bacteria

Answer 2

Macrophages

Question 3

IFN-y and IL-2 released by Th1 cells can activate ___________ and enable them to kill otherwise resistant intracellular bacteria

Answer 3

Macrophages

Question 4

The innate pathway by macrophage activation involves IFN-y and production of ___ cells

Answer 4

NK

Question 5

Depending on their ______ exposure, macrophages can be classically activated (M1) or alternatively activated (M2)

Answer 5

Cytokine

Question 6

Which macrophage- M1 or M2- has the major regulatory role and are critical to granuloma formation and wound healing ?

Answer 6

M2

Question 7

Classical activation- M1- leads to ?

Answer 7

Inflammation

Question 8

The following increase- M1 or M2?
Resolution of inflammation
Wound repair
Extracellular matrix prodcution
Cell proliferation
Angiogenesis

Answer 8

Alternative activation- M2

Question 9

What type of bacteria can infect macrophages and induce antigen processing?

Answer 9

Mycobacteria

Question 10

When macrophages are in contact with listeria:
Normal macrophages initially ______ bacteria, but then it grows again
Activated macrophages, bacteria is _______

Answer 10

Decreased
Eliminated

Question 11

Killing of infected target cells by CD8 + T cells is ________

Answer 11

Specific

Question 12

Memory and killing occurs in the ________ tissue

Answer 12

Peripheral

Question 13

Macrophage activation occurs in?

Answer 13

Lymphoid tissue