Histow Flashcards
% composition of enamel? What is the main mineral component?
96% inorganic
Calcium phosphate aka Hydroxyapatite arranged in prisms
1% amelogenins (main protein) and enamelins contained in enamel tuft
3% water
*Dentin: 70% inorg
*cementum: 55% inorg (calcium salts)
Enamel prisms are arranged…
Approximately PERPENDICULAR to the dentin at the dentinoenamel junction following a wavy course towards enamel surface
Gnarled enamel vs straight enamel
Gnarled enamel - prisms are twisted in a random manner, located over cusps and ridges of premolars and molars, rarely fractures
Shallow, transverse, wavelike grooves visible under reflected light parallel to the CEJ, surface manifestation of the lines of Retzius
Perikymata / imbrication line of Pickerill
- encircles the surface of enamel on anatomic crown
Some sources: perikymata - cervical ridges
Imbrication lines - grooves between
Brown lines seen in ground sections at the enamel
Incremental striae (lines of Retzius)
-indicate variations in deposition of organic matter in enamel which later calcifies
Hypomineralized area
Line where enamel is being deposited at birth
Neonatal line
- represents accentuated lines of Retzius
- reflects metabolif changes at birth
-present in dentin
Enamel Internal to it: formed before birth and has fewer defects
Enamel External to it: formed after birth
Alternating light and dark bands seen under oblique reflected light in longitudinal ground sections
Hunter-Schreger bands - DEJ to external surface of enamel / inner 2/3 of enamel (due to periodic changes in the enamel prism direction)
LIGHT ZONE: PARAZONE
DARK ZONE: DIAZONE
Area of poorly calcified enamel that extend from outer surface into the tissue for variable distances
Enamel lamellae - sometimes completely through underlying dentin
Extension of adjacent odontoblastic processes that continue into enamel (left behind kasi)
Enamel spindles - various terminations (pointed, sharp, rounded)
Areas of hypocalcification in prisms and interprismatic material (calcification imperfections in enamel prisms) that starts at DEJ and penetrates into enamel
Enamel tufts - start at DEJ and penetrate into enamel about 1/3 of its thickness
Enamelin: organic material in enamel tufts
Some patients experience pain on tooth may be due to:
A. Enamel Tufts
B. Enamel lamellae
C. Enamel spindles
D. Striae of Retzius
C
Cause of sclerosis in dentinal tubules
Increase formation of peritubular dentin = decrease permeability
Optical phenomenon due to cyclic activity of the odontoblasts during dentin formation
Incremental lines of von Ebner (perpendicular to the dentinal tubules)
Sa DENTIN TO!!
Completion of radicular dentin formation
(closure of apex)
Primary: 18months after eruption
Permanent: 2-3yrs after eruption
Tomes fiber vs tomes process
Odontoblastic process: tomes fiber
Ameloblast extension: tomes process (responsible for enamel secretion)
Main bulk of dentin?
Intertubular dentin
Immediate wall material which is the peritubular dentin was previously called?
Sheath of Neumann
Type of dentin that lines the pulp?
Secondary dentin -can sometimes obliterate the pulp
Type of dentin that develops at localized sites stimulated by local irritation
Tertiary or reparative or irregular dentin
Type of dentin resulting from stimuli that causes calcification of the odontoblastic process
Sclerotic or transparent dentin - hypercalcification = harder and denser dentin
Seen where tome’s process has disintegrated
Dead tracts in dentin - black in transmitted light, white in reflected light
Location of cellular and acellular cementum
Acellular deposited slowly from CEJ to 2/3 of root
Cellular rapidly forms and predominantly in apical 3rd and furcations
Two types mingle in the apical 3rd of the root
Most common type of CEJ
Acellular cementum overlaps the cervical enamel (60%)
Cementum and enamel meet at a sharpt point (30%)
No direct connection (10%)
Involved in dentin formation that originates in the pulp
First sign of mantle dentin formation
Von Korff’s fibers - type 3 collagen fibers (reticular) + fibronectin
Calcospherites failed to fuse completely will result to?
Areas of dentin matrix with tubules that are incompletely calcified (interglobular dentin frequently near DEJ)
Principal fibers that can prevent rotation of the tooth and preclude occlusal displacement
Alveloar crest fibers - cervical cementum to alveolar crest
**Horizontal fibers can also check rotation of the tooth (cervical cementum horizontally to alveolar bone)
Principal fiber that prevents tooth from being forced into the socket
Oblique fibers - cementum occlusally to alveolar bone (obliquely), largest group
Fibers that prevent rotation of tooth by radiating out like a fan from the apical region of root
Apical fibers
Fibers that maintain the mesiodistal relations
Transseptal fibers
Alveolar process two regions: internal cancellous layer and lamina dura. Other name for lamina dura?
Cribriform plate - it contains many apertures for vessels coursing between the marrow cavities and the PDL
Type of bone that lines the socket after teeth have been subjected to stress
Bundle bone
periods of prenatal development
proliferative (0-2 weeks IU) least vulnerable
embryonic (2-8 weeks IU) most vulnerable
fetal (8 weeks-9 months)
16 cell zygote
morula
blastocysts is when there is a fluid filled center (yolk sac)
lines the primary yolk sac and aids implantation (becomes placenta)
trophoblast cells -digests endometrial cells
embryoblast will form bilaminar germ disk or embryonic disk (embryo proper)
two-layered disk
bilaminar germ disk or embryonic disk
becomes:
ectodermal layer: lines amniotic cavity
endodermal: lines yolk sac
before placenta forms, what provides nutrition of embryo? … through??
yolk sac through vitelline arteries
week when bilaminar becomes trilaminar disk? what is it called?
period of gastrulation
3rd week of gestation
gastrulation and neurulation events
3rd week
ectodermal layer thickens (neural plate) –> neural folds –> neural groove –> meets at the middle –> neural tube (brain and spinal cord)
migration of neural crest cells/ ectomesenchyme (from ectoderm) becomes face and teeth EXCEPT ENAMEL; gives rise to neural, endocrine, pigment cells, skeleton, CT of head and neck
when: heart begins to beat?
4th week
derivatives of ectoderm, mesoderm, endoderm
ectoderm
nervous system
sensory epithelium of eye, ear, nose
mammary and cutaneous glands
epithelium of the sinuses, oral and nasal cavities, intraoral glands
tooth enamel
CT of head and neck
mesoderm
muscles
CT derivatives (bone, cartilage, blood, PDL, cementum, pulp etc)
endoderm
GI tracct
lungs
liver, gallbladder, pancreas
urinary bladder
when is the neural tube formed/fused?
18 days - 20 days
when: facial development
3rd to 7th week IU
four major tissue masses for facial development
frontonasal process
LEFT AND RIGHT maxillary processes (PA1)
mandibular process (PA1)
3rd Week IU
rapidly developing brain + heart = embryo folds
*stomodeum - primitive mouth; bounded by frontal prominence and PA1
*presence of buccopharyngeal membrane (ectoderm and endoderm)
end of 3rd week: first PA has divided into right and left Maxillary process and mandibular process
separates the primitive mouth from the foregut
buccopharyngeal membrane - ecto and endoderm
4th week IU
buccopharyngeal membrane disintegrates
nasal pits on the frontonasal process –> median nasal process, left and right lateral process
heart begins to beat
tongue begins to develop
5th week IU
fusion of medial nasal process –> philtrum, middle of upper lip, **globular process* –> primary palate/premaxilla
lateral nasal process forms the ala of nose
eyes become prominent at the side
Md arch loses midline constriction
6th week IU
lateral growth of brain
broadening of face
upper lip forms (MxP + MNP)
6 auricular hillocks (hillocks of His) - from BA1 and BA2 (pharyngeal grooves?) –> external ear
7th week IU
eyes approach front of face
development of the secondary palate –> completed by 3rd month
maxi process –> two palatine shelves develop –> secondary palate
palatine shelves + nasal septum –> separation of oral and nasal cavities
PALATE DEVELOPMENT
what forms the upper lip??
Maxillary process + median nasal process
*failure of fusion = cleft lip
when and how: palate development
starts 7 weeks IU
palatal closure: approx 12 weeks
from globular process of MNP –> premaxilla/primary palate
from palatine shelves of L&R maxi process –> secondary palate
*FUSION OF PRIMARY is from posterior to anterior
*FUSION OF SECONDARY is from anterior to posterior
**may contact sa gitna kasii tas dun magstart magfuse
when and how: development of tongue
4 weeks IU
anterior 2/3
-right and left lateral swellings + tuberculum impar of (BA1)
posterior 1/3 - posterior to old buccopharyngeal membrane
-Copula (BA2) + hyprobranchial eminence (BA3 and BA4) –> eminence grows OVER copula (matatakpan)
-epiglottal swelling (BA4)
marks the development of epiglottis
posterior part of the 4th BA (epiglottal swelling
former location of thyroid gland
foramen cecum –> bababa thyroid with thyroglossal duct (parang string then mawawala)
facial and palatal clefts: critical period?
6th and 7th week IU
oblique facial cleft is the failure of fusion of?
lateral nasal process and maxillary process
bilateral cleft lip is the failure of fusion of?
median nasal process and left and right maxillary process
median cleft lip is the failure of fusion of?
left and right median nasal process at midline
*magkalayo ang median nasal process before kasi
lateral facial cleft is the failure of fusion of?
maxillary process and mandibular process
only BA that extend to the midline??
BA1 and BA2
How was the smooth surface of neck formed? when?
fusion of BA2 and BA5 to eliminate features of 2, 3, 4 BA
5th week!
BA1 structures?? (Mandibular arch)
Maxillary artery
Trigeminal nerve
MOMs
tensor tympani and tensor veli palatini
mylohyoid
anterior belly of digastric
malleus, incus, sphenomandibular, Meckel’s
external ear, middle ear, eustachean tube
BA2 structures?? (hyoid)
hyoid artery, stapedial artery
facial nerve
MOF
stapedius, stylohyoid, POSTERIOR digastric
stylohyoid ligament
LESSER horn of hyoid
supratonsillar fossa
BA3 structures
internal carotid artery
glossopharyngeal nerve
stylopharyngeus
GREATER horn of the hyoid
INFERIOR parathyroid gland
thymus