History of drugs Flashcards
reintroduced clozapine into clinical practice
Kane
developed the first SSRI (modified pheniramine to create zimelidine)
Carlsson
first described the ‘cheese effect’ seen in MAOI use
Blackwell
discovered lithium’s beneficial effect in mania
Cade
discovered use of iproniazid (MAOI)
Kline
synthesised chlorpromazine
Charpentier
introduced chlorpromazine as a treatment for schizophrenia and coined the term ‘neuroleptic’
Delay and Deniker
discovered the antidepressant effects of imipramine
Kuhn
first use of ECT
Cerletti (and Bini)
coined the term ‘antidepressant’
Lurie
insulin shock therapy
Sakel
frontal leucotomy for psychosis
Moniz
metrazol therapy
Meduna
What was chlorpromazepine used by in 1951 for first time
by Laborit and Huguenard, for its potential anesthetic effects during surgery who noticed it produced disinterest without loss of consciousness and with only a slight tendency to sleep.
When was introduction of clozapine treatment?
1990 - opened the era of ‘atypical’ antipsychotics.
When was clozapine first synthesised
First synthesised in 1958 (from imipramine)
Clozapine was removed from most markets in 1975 why
after deaths from agranulocytosis.
What was the first antidepressant and what was it developed for
the MOA inhibitors (namely iproniazid). Iproniazid was initially developed as a treatment for tuberculosis.
Why were TCAs developed
the search was on for even more potent antipsychotic compounds
When was imipramine approved
1959
Which were the only class of antidepressants that were actually developed for their intended use
SSRIs
Zimeldine, which was derived from pheniramine (in the late 1960s), was marketed in Europe in 1982 but then removed in 1983 due what?
to severe side effects such as hypersensitivity reactions and Guillain-Barre syndrome, which is acute peripheral neuropathy.
The hypersensitivity reactions resembled a flu- like syndrome
