Clozapine

Question 1

What is clozapine classified as structurally

Answer 1

tricyclic dibenzodiazepine derivative.

Question 2

Has a particularly high affinity for which receptor

Answer 2

D4 receptors

Question 3

More active at which location of receptors?

Answer 3

at the limbic than at striatal dopamine receptors

Question 4

Effect on prolactin?

Answer 4

minimal

Question 5

List the receptors affected by clozapine

Answer 5

Dopaminergic
Histaminergic
Serotonergic
Adrenergic
Cholinergic

Question 6

Mainly metabolised by what?

Answer 6

CYP1A2

Question 7

Which drugs increase plasma clozapine levels?

Answer 7

SSRI’s
Erythromycin
Caffeine

Question 8

Which drugs decrease plasma clozapine levels?

Answer 8

Carbamazepine
Phenytoin
Tobacco

Question 9

When is hypersalivation worse

Answer 9

at night and during the early stages of therapy.

Question 10

Caution should be used in which circumstances?

Answer 10

prostatic hypertrophy
susceptibility to angle-closure glaucoma
adult over 60 years

Question 11

When using clozapine valproate should be considered when?

Answer 11

Using high doses
Plasma levels > 0.5 mg/l
Patient experiences seizures

Question 12

Most cases of myocarditis occur when

Answer 12

early in the course of clozapine treatment

Question 13

The gold standard for diagnosis of myocarditis is what?

Answer 13

an endomyocardial biopsy