Alzheimer's dementia

Question 1

Describes genetics of Alzheimers sporadic vs inherited?

Answer 1

*most cases are sporadic
*5% of cases are inherited as an autosomal dominant trait

Question 2

Mutations where cause inherited form Alzheimers

Answer 2

*mutations in the amyloid precursor protein (chromosome 21), presenilin 1 (chromosome 14) and presenilin 2 (chromosome 1) genes are thought to cause the inherited form

Question 3

Which apo protein involved in Alzheimers

Answer 3

*apoprotein E allele E4 - encodes a cholesterol transport protein

Question 4

What are neurofibrillary tangles and what are they like in AD?

Answer 4

*paired helical filaments are partly made from a protein called tau
*in AD are tau proteins are excessively phosphorylated

Question 5

Name the three ACh inhibitors used as options for managing mild to moderate Alzheimer’s disease

Answer 5

donepezil, galantamine and rivastigmine

Question 6

What type of drug is mematine?

Answer 6

NMDA receptor antagonist