Cytochrome system Flashcards
1
Q
Which cytochrome shows the largest phenotypic variation amongst the cytochromes?
A
CYP2D6
2
Q
Which cytochrome is involved in metabolism of clozapine.
A
CYP1A2
3
Q
What does grapefruit juice do to CYP1a2 and therefore clozapine levels?
A
inhibits CYP1A2 and therefore can increase clozapine levels.
4
Q
smoking
A
inducer
5
Q
alcohol and barbituates
A
inducer
6
Q
carbamazepien
A
inducer
7
Q
phenytoin
A
inducer
8
Q
St John’s Wort.
A
inducer
9
Q
chlorpromazine
A
inhibitor
10
Q
grapefruit
A
inhibitor
11
Q
SSRI
A
inhibitor
