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Psychopharmacology > Antidepressants > Flashcards

Antidepressants Flashcards

1
Q

mCPP is active metabolite for what?

A

trazodone

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2
Q

Which antidepressant can be effective sublinguillay

A

fluoxetine

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3
Q

Which antidepessant can be given bucally/transdermally

A

selegeline

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4
Q

Post MI recommended SSRI

A

sertraline

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5
Q

Which antidepressants should be avoided in those with risk of arrythmia

A

Bupropion, citalopram, escitalopram, moclobemide, lofepramine and venlafaxine

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6
Q

Which TCA is less cardiotoxic

A

Lofepramine

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7
Q

Is the arrhythmogenic potential of TCAs and other antidepressants dose dependent?

A

yes

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8
Q

Which should be avoided in diabetes

A

TCAs and MAOIs

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9
Q

What may the following symptoms suggest:
Flu-like symptoms
Dizziness
Insomnia
Vivid dreams
Irritability
Crying spells
Sensory symptoms (e.g. sensations resembling electric shocks in the arms, legs, or head)

A

SSRI discontinuation syndrome

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10
Q

What type of drug is venlafaxine

A

SNRI

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11
Q

Discontinuation symptoms seem least likely with which SSRI

A

fluoxetine

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12
Q

Which antidepressants are most associated with discontinuation symptoms

A

Paroxetine (SSRI)
Venlafaxine (SNRI)

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13
Q

TCAs particularly associated with discontinuation symptoms include which?

A

Amitriptyline
Imipramine

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14
Q

The following are discontinuation symptoms of which antidepressant type?
Agitation/ irritability
Ataxia
Movement disorders
Insomnia
Vivid dreams

A

MAOI

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15
Q

Risk factors for discontinuation symptoms?

A

those on antidepressants with shorter half lives
those who have been taking antidepressants for 8 weeks or longer (longer duration of treatment)
those using higher doses
those who developed anxiety symptoms at the start of antidepressant therapy
those receiving other centrally active medications (e.g. antihypertensives, antihistamines, antipsychotics)
younger people
those who have experienced discontinuation symptoms before

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16
Q

TCA discontinuation symptoms?

A

Flu-like symptoms
Insomnia
Excessive dreaming

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17
Q

When do discontinuation symptoms usually occur

A

usually within 5 days of stopping but varies depending on half life

18
Q

How quickly do discontinuation symptoms resolve if medication recommenced?

A

usually resolve fully within 24 h if the original antidepressant is recommenced

19
Q

Which antidepressants may be used for Nocturnal enuresis in children

A

Amitriptyline, Imipramine, Nortriptyline

20
Q

Which antidepressants may be used for phobic and obsessional states?

A

clomipramine

21
Q

Which antidepressant can be used for Adjunctive treatment of cataplexy associated with narcolepsy

A

clomipramine

22
Q

Which antidepressants are licensed for agoraphobia and panic disorder?

A

Citalopram, Escitalopram, Sertraline, Paroxetine, Venlafaxine

23
Q

Which antidepressants are licensed for agoraphobia and panic disorder?

A

Citalopram, Escitalopram, Sertraline, Paroxetine, Venlafaxine

24
Q

Which additional antidepressant is licensed for social anxiety

A

Moclobemide

25
Q

Antidepressant licensed for bulimia?

A

Fluoxetine

26
Q

Antidepressants licensed for OCD?

A

Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline

27
Q

Antidepressants licensed for PTSD?

A

Paroxetine and Sertraline

28
Q

How does duloxetine work

A

Serotonin and noradrenaline reuptake inhibitor (SNRI) also weak inhibitor of dopamine reuptake

29
Q

How does venlafaxine work

A

Serotonin and noradrenaline reuptake inhibitor (SNRI)

30
Q

How does reboxetine work

A

Noradrenaline reuptake inhibitor (NRI)

31
Q

How does bupropion work

A

Noradrenaline and dopamine reuptake inhibitor (NDRI)

32
Q

How does trazadone work

A

Weak SRI and 5HT agonist

33
Q

How does St Johns wort work

A

Weak MAOI and weak SNRI

34
Q

How does mirtazepine work?

A

Noradrenaline and serotonin specific antidepressant (NaSSa).
5HT-1, 5HT-2, 5HT-3, H1 antagonist,
presynaptic alpha 2 antagonist (which stimulates the release of NA and 5HT)

35
Q

Minimum effective dose of mirtazepine?

A

30 mg / day

36
Q

Minimum effective dose of trazadone?

A

150 mg / day

37
Q

Which TCAs are most dangerous in overdose?

A

amitriptyline and dosulepin (dothiepin)

38
Q

Which SSRI most likely to cause weight gain

A

Paroxetine

39
Q

Which medications are less likely than SSRIs to cause weight gain

A

bupropion and nefazodone

40
Q

Which antidepressant types most likely to cause weight gain?

A

tricyclic antidepressants (TCAs) and perhaps monoamine oxidase inhibitors (MAOIs)

Psychopharmacology (19 decks)

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