High Yield Topics-Psychiatry Flashcards

1
Q

Characterized by fear, anxiety, or avoidance of separation from major attachment figures; beyond the age-appropriate range; often a precursor to school refusal behavior (false physical complaints)

A

Separation anxiety disorder

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2
Q

Separation anxiety is, to some extent, developmentally appropriate for children between what age group

A

< 4 years

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3
Q

Time of duration needed to be diagnosed for shizophrenia

A

> 6 months

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4
Q

Time of duration needed to be diagnosed for shizophreniform

A

> 1 month but < 6 months

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5
Q

Time of duration needed to be diagnosed for brief psychotic disorder; usually develops after stressful life-events.

A

< 1 month

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6
Q

The major difference b/w schizophrenia vs. schizoaffective disorder

A

In schizoaffective disorder, mood symptoms can be the majority of the illness as a prominent feature in addition to psychotic symptoms. In schizophrenia, mood symptoms are NOT the dominant feature.

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7
Q

Time of duration needed to be diagnosed for schizoaffective disorder

A

> 2 weeks

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8
Q

A disorder with psychotic symptoms that appear exclusively during manic or depressive episodes

A

Mood disorder with psychotic features

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9
Q

A disorder with only delusion (false belief) without any other psychotic symptoms

A

Delusional disorder

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10
Q

Time of duration needed to be diagnosed for Delusional disorder

A

> 1 month

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11
Q

Time of duration needed to be diagnosed for major depressive disorder

A

at least 2 weeks

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12
Q

Time of duration needed to be diagnosed for Persistent depressive disorder (dysthymia)

A

at least 2 years

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13
Q

Manic episodes with or without major depressive episodes

A

Bipolar I disorder

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14
Q

Hypomanic episodes + major depressive episodes

A

Bipolar II disorder

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15
Q

Persistent instability of mood involving numerous periods of depression and periods of hypomania

A

Cyclothymia

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16
Q

Time of duration needed to be diagnosed for Bipolar I disorder

A

Manic episode lasting ≥ 1 week

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17
Q

Time of duration needed to be diagnosed for Bipolar II disorder

A

Hypomanic episode lasting ≥ 4 consecutive days + Major depressive episode for at least 2 weeks

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18
Q

Time of duration needed to be diagnosed for Cyclothymia

A

≥ 2 years

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19
Q

distressing symptoms related to a specific traumatic event and lasting > 1 month following the event

A

Post-traumatic stress disorder (PTSD)

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20
Q

distressing symptoms related to the traumatic event that last between 3 days to 1 month following the exposure

A

Acute stress disorder

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21
Q

a maladaptive emotional (anxiety) or behavioral (outburst) response to a stressor, symptoms lasting ≤ 6 months following resolution of the stressor;

A

Adjustment disorder

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22
Q

pronounced fear or anxiety of being in situations that are perceived as difficult to escape from

A

Agoraphobia

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23
Q

recurrent spontaneous and unexpected panic attacks that often occur without a known trigger

A

Panic disorder

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24
Q

Which generation of antipsychotics blocks only positive symptoms of schizophrenia by blocking dopamine receptors

A

First generation (typical)

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25
Q

Which generation of antipsychotics blocks both dopamine (positive symptoms) and serotonin (negative symptoms) receptors

A

Second generation (atypical)

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26
Q

Which generation of antipsychotics is used for long term treatment of schizophrenia

A

Second generation (atypical)

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27
Q

Common endings of second generation (atypical) antipsychotics

  • Know them cold!!!
A
  • zapine/pine
  • sidone/ridone
  • prazole
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28
Q

Mnemonic for second generation (atypical) antipsychotics

A

CROZAQ

  • clozapine
  • risperidone
  • olanzapine
  • ziprasidone
  • aripipirazole
  • quetiapine
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29
Q

Side effects of second generation (atypical) antipsychotics

A

Weight gain/metabolic syndrome, EPS (akathisia, dystonia, parkinsonism, and tardive dyskinesia), and prolonged QTc

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30
Q

degrades biogenic amine neurotransmitters (eg, serotonin, dopamine, norepinephrine, epinephrine)

A

Monoamine oxidase

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31
Q

inhibit the enzymatic activity of monoamine oxidase and thereby increase the synaptic concentrations of these neurotransmitters

A

Monoamine oxidase inhibitors (MAOIs)

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32
Q

MAOIs are effective for depression and anxiety but are typically used only after other agents have failed because of the risk for what serious adverse effects?

A
  1. Hypertensive crisis
    - MAOIs decrease peripheral degradation of tyramine (which normally gets degraded by MAO) –> hypertensive crisis can result from tyramine displacing stored monoamines such as dopamine, norepinephrine, and epinephrine from synaptic vesicles
  2. Serotonin syndrome
    - Combining MAOIs with other serotonergic agents increases the risk for serotonin syndrome
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33
Q

a cluster A personality disorder that features odd or magical thinking, perceptual disturbances, social isolation (because of mistrust of others), and a constricted affect.

A

Schizotypal personality disorder

  • Know this cold!!
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34
Q

a cluster A personality disorder that manifests with social indifference, social isolation, and a decreased range of emotions

A

Schizoid personality disorder

  • Know this cold!!
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35
Q

the patient is preoccupied with one or more somatic symptoms such that these symptoms disrupt the patient’s daily life

A

somatoform disorder (aka. somatic symptom disorder)

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36
Q

Act by binding to the allosteric site of GABA receptor –> results in Cl- channel opening and influx of chloride ions into the neurons –> Neuronal hyperpolarization and inhibition of the action potential

A

Benzodiazepines

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37
Q

Flat affect (ie, reduced emotional expressiveness), decreased attention to personal hygiene, and thought blocking (ie, sudden inability to finish a thought) are findings typical of

A

schizophrenia

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38
Q

Low self-esteem, psychomotor slowing (ie, slow speech and movements), and social withdrawal are findings typical of

A

major depressive episode

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39
Q

pressured speech, racing thoughts, and grandiosity are findings typical of

A

Manic episodes (bipolar disorder)

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40
Q

Intoxication of (stimulant/depressants) present with nonspecific symptoms such as mood elevation, decreased anxiety, sedation, behavioral disinhibition, respiratory depression

A

depressants

  • Alcohol
    Opioids (morphine, heroine, methadone)
    Barbiturates
    Benzodiazepines
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41
Q

Withdrawal of (stimulant/depressants) present with nonspecific symptoms such as anxiety, tremor, seizures, insomnia

A

depressants

  • Alcohol
    Opioids (morphine, heroine, methadone)
    Barbiturates
    Benzodiazepines
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42
Q

Intoxication of ____ presents with emotional lability (changes), Slurred speech, Ataxia, blackouts

A

Alcohol

43
Q

What is the sensitive serum indictor of alcohol use?

A

Increased GGT (y-glutamyltransferase)

44
Q

What LFT is indicative of alcohol use?

A

AST: ALT is 2:1 ratio

45
Q

Withdrawal of ____ presents with

  1. anxiety, diaphoresis/agitation, tremor, GI upset
  2. withdrawal seizure
  3. Hallucinations
  4. Delirium tremens (tremor)
A

alcohol

46
Q

Tx for alcohol withdrawal symptoms including delirium tremens

A

Benzodiazepines

47
Q

Long-term tx for alcoholism that reduces cravings

A

Naltrexone or Acamprosate

48
Q

Long-term tx for alcoholism that acts as a deterrent by producing unpleasant/negative symptoms when used with alcohol

A

Disulfiram

49
Q

Delirium tremens is characterized by electrolyte disturbances and respiratory

A

alkalosis

  • Hyperventilation causes increased loss of PaCO2
50
Q

Tachycardia, tremors, anxiety, seizures of delirium tremens is characterized by autonomic

A

hyperactivity

51
Q

Delirium tremens usually occurs in what setting?

A

Hospital

*since patient cannot drink when hospitalized

52
Q

Intoxication of ____ presents with Euphoria, respiratory / CNS depression, Decreased gag reflex, Miosis

A

Opioids

53
Q

Withdrawal of ____ presents with seizure, Sweating, Mydriasis, Piloerection, yawning, lacrimation + flu-like symptoms (diarrhea, stomach cramps, nausea)

A

Opioids

54
Q

Tx for opioid overdose

A

Naloxone

55
Q

a long-acting oral “opiate” used for opioid detoxification or long-term maintenance therapy

A

Methadone

56
Q

a long-acting opioid “antagonist” used for relapse prevention once detoxified from opiates

A

Naltrexone

57
Q

What mu opioid antagonist must be given parenterally (other than orally) to avoid inactivation by 1st pass metabolism through mouth

A

Naloxone

58
Q

What drug intoxication presents as respiratory and CNS depression, pinpoint pupils and decreased gag reflex?

A

Opioids

59
Q

What drug combination may be used for maintenance therapy following opioid detoxification?

A

Buprenorphine (opioid partial agonist) + naloxone

  • naloxone is added to lower IV abuse potential
60
Q

What drug class is the most common cause of drug overdose death?

A

Opioids

61
Q

Opioid withdrawal presents with pupillary

A

Mydriasis (dilation)

62
Q

Opioid intoxication presents with pupillary

A

Miosis (constriction)

63
Q

Intoxication of ____ presents with marked respiratory depression

A

Barbiturates

64
Q

Withdrawal of ____ presents with delirium and life-threatening cardiovascular collapse

A

Barbiturates

65
Q

Intoxication of ____ presents with ataxia

minor respiratory depression

A

Benzodiazepines

66
Q

Withdrawal of ____ presents with Sleep disturbance and depression

A

Benzodiazepines

67
Q

Tx for Benzodiazepines overdose

A

Flumazenil

68
Q

MOA of Flumazenil

A

Benzodiazepine receptor antagonist

69
Q

Why is flumazenil rarely used to treat Benzodiazepines overdose

A

b/c it can cause seizure

70
Q

Intoxication of (stimulant/depressants) present with nonspecific symptoms such as euphoria, insomnia, arrhythmias, tachycardia, anxiety

A

stimulants

*amphetamines, cocaine, caffeine, nicotine

71
Q

Withdrawal of (stimulant/depressants) present with nonspecific symptoms such as depression, lethargy, post-use crash, vivid nightmares

A

stimulants

*amphetamines, cocaine, caffeine, nicotine

72
Q

Intoxication of ____ presents with grandiosity, mydriasis, hyperalertness, HTN

A

Amphetamines

73
Q

Withdrawal of ____ presents with depression, lethargy, post-use crash, vivid nightmares

A

Amphetamines

74
Q

What skin finding can be found with Amphetamines overdose?

A

skin excoriations (rash and ulcers)

  • Methamphetamine especially!
75
Q

Tx for Amphetamine overdose agitation and seizure

A

Benzodiazepines

76
Q

Intoxication of ____ presents with palpitation, agitation, tremor, insomnia

A

Caffeine

77
Q

Withdrawal of ____ presents with HA, can’t concentrate

A

Caffeine

78
Q

Intoxication of ____ presents with impaired judgment, pupillary dilation, hallucinations, paranoid ideations, angina, sudden cardiac death

A

Cocaine

79
Q

Withdrawal of ____ presents with psychomotor retardation, depression, lethargy

A

Cocaine

80
Q

What unique finding is associated with chronic use of cocaine?

  • HINT: sniffing
A

perforated nasal septum

  • caused by vasoconstriction –> ischemic necrosis –> perforation
81
Q

Tx for Cocaine overdose

A
  • Benzodiazepines

- mixed a/B blocker (labetalol)

82
Q

Intoxication of ____ presents with restlessness

A

nicotine

83
Q

Withdrawal of ____ presents with increased appetite
Irritability
Anxiety
Can’t concentrate

A

nicotine

84
Q

Tx for nicotine withdrawal that inhibits BOTH NE and D2 reuptake

A

bupropion

85
Q

What antidepressant can also be used as a tx for smoking cessation and has low risk of ED as an adverse effect?

A

bupropion

86
Q

Tx for nicotine withdrawal that acts as a nicotinic receptor PARTIAL AGONIST

A

varenicline

  • STUDY AID: sketchypharm (very clean)
87
Q

Intoxication of ____ presents with perceptual distortion (visual, auditory), depersonalization, “flashbacks”

  • HINT: think about the drug’s “colorful” stickers!
A

LSD (Lysergic Acid Diethylamide)

88
Q

What category of drugs present similar to stimulant overdose + hallucinations when intoxicated?

A

Hallucinogens

- LSD, Marijauna, MDMA, PCP

89
Q

Intoxication of ____ presents with conjunctival injection (red eyes), euphoria, perception of slowed time, social withdrawal, increased appetite, dry mouth, hallucinations

A

Marijauna

90
Q

Withdrawal of ____ presents with irritability, depression, decreased appetitie

A

Marijauna

91
Q

Intoxication of ____ presents with hallucinations, increased thirst, bruxism, HTN, tachycardia, and hyperthermia.

A

MDMA (methylenedioxy-methylamphetamine)

aka. Ecstasy

92
Q

MDMA overdose can present with what life-threatening effect by activating serotonin receptors?

A

Serotonin syndrome

93
Q

MDMA is aka.

A

Ecstasy

94
Q

Bruxism is aka.

A

teeth grinding

95
Q

Withdrawal of ____ presents with depression, can’t concentrate

A

MDMA

96
Q

Intoxication of ____ presents with violence, impulsivity, analgesia (can’t feel pain), nystagmus, and psychosis

A

Phencyclidine (PCP)

  • violent and dangerous!
97
Q

What is the most common complication of Phencyclidine (PCP) overdose?

A

Trauma (b/c of its violence, impulsivity, analgesia adverse effects)

98
Q

What condition presents with a triad of encephalopathy (confusion), ophthalmoplegia, and ataxia?

A

Wernicke Encephalopathy

99
Q

What condition presents with irreversible retrograde and anterograde memory loss, personality change, and confabulation?

A

Korsakoff syndrome

100
Q

Tx for Wernicke0Korsakoff syndrome

A

IV B1 (thiamine) BEFORE dextrose!

101
Q

Caused by any drug that ↑ 5-HT, leading to ↑ neuromuscular activity (hyperreflexia, hypertonia, seizure), autonomic instability (diarrhea, diaphoresis, hyperthemia), and altered mental status

A

Serotonin syndrome

102
Q

In order to avoid Serotonin syndrome, what is required after discontinuing a MAOI and before initiating SSRI therapy?

A

2 week washout period to allow time for monoamine oxidase (MAO) regeneration

103
Q

Tx for serotonin syndrome

A

Cyproheptadine (5-HT receptor antagonist)