High Yield Topics-Endocrine Flashcards
The type of vitamin D that is obtained from exposure of skin to sun or through ingestion from dairy products
vitamin D3 (aka. Cholecalciferol)
The type of vitamin D that is obtained from ingestion of plants, fungi, and yeasts
vitamin D2 (Ergocalciferol)
- STUDY AID: think of ERGOsterol in FUNGAL cell membrane
Both cholecalciferol and ergocalciferol convert into what storage and active forms?
- 25-OH D3 (storage form)
- 1,25-(OH)2D3 (active form; calcitriol)
cholecalciferol and ergocalciferol convert into storage form in what organ?
liver
cholecalciferol and ergocalciferol convert into active form (calcitriol) in what organ?
kidney (PCT)
Why is vitamin D required to increase serum Ca+2 level?
Active Vitamin D increases intestinal absorption of Ca+2 (and PO43- also)
Enzyme that converts inactive/storage form (25-hydroxyvitamin D) to active form (1,25-dihydroxyvitamin D)
1α-hydroxylase
- mainly in the kidneys
A disorder causing ↑ β-adrenergic receptor expression, leading to ↑ catecholamine effects; presents with SYSTOLIC hypertension, sweating, hot intolerance, diarrhea, warm/moist skin, palpitations/tachycardia, weight loss, hyperreflexia, and can mimic anxiety disorder
Hyperthyroidism
An autoimmune disordercaused by thyroid-“stimulating” antibody that binds and stimulates TSH receptors on thyroid; presents with hyperthyroid symptoms
Graves Disease
Caused by orbital fibroblasts
and T-Cells activation by thyrotropin (aka. TSH) receptor antibodies –> cytokine release (TNF-a, IFN-Y) –> glycosaminoglycan (GAG) deposition in eyes –> expansion/inflammation of extraocular muscles –> exophthalmos (protruding eyes)
Graves Ophthalmopathy
Lab findings of Hyperthyroidism
TSH, T4, T3, TBG
TSH:↓
T4: ↑
T3: ↑
TBG: normal
Improve Graves ophthalmopathy by decreasing the severity of inflammation and reducing the excess extraocular volume
Glucocorticoids
Caused by accumulation of GAGs in leg skin due to activation of dermal fibroblasts by thyroid-stimulating antibodies
Pretibial myxedema
The adrenergic receptor symptoms (systolic hypertension, sweating, hot intolerance, palpitations/tachycardia, hyperreflexia) can be relieved by what drug?
β blockers
Drugs that ↓ the formation of TSH (thyrotropin) via inhibition of thyroid peroxidase, the enzyme responsible for both iodine organification and coupling of iodotyrosines
Thioamides
- methimazole
- PTU
Which Thioamide also decreases the peripheral conversion of T4 to T3?
PTU
A serious complication of Thioamides that results in granulocyte destruction and consequent neutropenia; initially presents with fever, sore throat, and oral ulcerations
Agranulocytosis
If drug-induced agranulocytosis is suspected, what should be done?
Discontinue the drug and obtain CBC w/ diff to confirm diagnosis
A condition characterized by ↑ free T4, suppressed TSH, and low/undetectable TG; occurs with surreptitious levothyroxine abuse, use of animal-sourced thyroid supplements, and erroneous dosing of thyroid replacement therapy
Exogenous Hyperthyroidism
aka. Thyrotoxicosis
The lack of TSH stimulation continued by Exogenous Hyperthyroidism (levothyroxine) can lead to
ATROPHIC thyroid follicles
The main regulator of lipid metabolism by stimulating the mobilization and degradation of lipids (TG)
Thyroid hormone
- TH ↓TG
HLA (Human MHC) associated with Graves disease (2)
- HLA-DR3
2. HLA-B8
Caused by hyperfunctioning follicular cells (hot nodules) due to TSH receptor mutations and not due to increased TSH; ↑ release of T3 and T4
Toxic Multinodular Goiter
(Hot/cold) nodules produce excess thyroid hormone, show up on the scan because they take up more of the isotope than normal thyroid tissue, and almost always are NONcancerous
Hot nodules
(Hot/cold) nodules take up less of the isotope and ARE cancerous
Cold nodules
Occurs when hyperthyroidism is left untreated and gets worse during stress (surgery, infection); presents with fever, diarrhea, delirium, and tachyarrhythmia
Thyroid Storm
The condition that occurs when large amount of excess iodide (counterintuitive) is given as a tx for thyroid storm or thyrotoxicosis –> inhibits thyroid hormone synthesis
Wolff-Chaikoff Effect
What is hyperthyroidism that occurs following administration of iodine in a patient with iodine deficiency or autonomous nodule (nodule that autonomously produce thyroid hormone)?
- Opposite of Wolff-Chaikoff Effect
Jod-Basedow Effect
Autoimmune disorders (Graves , Hashimoto’s) and iodine deficiency cause (smooth or diffuse/nodular) goiter
smooth or diffuse
Toxic multinodular goiter and thyroid adenoma/cancer/cyst cause (smooth or diffuse/nodular) goiter
nodular
Benign solitary growth of thyroid that are nonfunctional (cold)
Thyroid adenoma
Histological finding of thyroid adenoma
Follicular (follicle-like)
Primarily produced by conversion from T4 in PERIPHERAL tissues; has a short ½ life
T3
Hypothyroidism causes ↓ expression of ____ receptors in the liver, leading to ↓ clearance of ____ and ↑ blood ____ levels
- ____ is all same
LDL
Hypothyroidism causes ↑ level of _____ , which ↑ the risk of coronary atherosclerosis
TG
The thyroid releases ___ and ____ in response to ____ from the pituitary, which is regulated by _____ from the hypothalamus
- T4 & T3
- TSH
- TRH
The most sensitive test for thyroid function; first to be outside the normal range in thyroid dysfunction
Serum TSH level
low TSH, low T3, low T4
Presents with myalgias, proximal muscle weakness, delayed relaxation of deep tendon reflexes, and “↑ CK” (creatine kinase) level due to hypothyroidism; diagnosis made by ↑ TSH
HYPOthyroid Myopathy
Inactive form of Triiodothyronine
rT3 (reverse T3)
- T3 is the active form
Ischemic necrosis of the pituitary gland (esp. anterior) that is typically caused by systemic hypotension during DELIVERY; may present with hypothyroidism and deficiency of other pituitary hormones
Sheehan Syndrome
_______ increase serum T4-binding globulin (TBG), thereby increasing serum total T4 concentrations; serum FREE (biologically active) T4 concentration remain normal via negative feedback
estrogen (pregnancy)
Biologically active T4 (thyroxine) is (bound/free)
free
An autoimmune disorder caused by antibodies against thyroid peroxidase (TPO) and thyroglobulin (substrate needed to make thyroid hormone); present as hyperthyroid early in course due to follicular rupture causing ↑ thyroid hormone release
Chronic Lymphocytic Thyroiditis
aka. Hashimoto
Histologically presents with lymphocytic infiltrate with germinal centers
Chronic Lymphocytic Thyroiditis
aka. Hashimoto
Large, pink-staining cells filled with granular cytoplasm seen in Hashimoto’s
Hürthle cells
- STUDY AID: “H”urthle cells for “H”ashimoto’s
HLA (Human MHC) associated with Hashimoto’s (2)
HLA-DR3
HLA-DR5
Hashimoto’s increase the risk of what lymphoma?
non-Hodgkin lymphoma
Fetal hypothyroidism caused by maternal hypothyroidism, thyroid dysgenesis, or iodine deficiency; presents with pot-bellied, puffy face, macroglossia (big tongue), big umbilicus, and poor feeding
Congenital hypothyroidism
Congenital hypothyroidism is aka.
Cretinism
A self-limiting condition following a viral illness like flu; presents with ↑ ESR and PAINFUL thyroid enlargement
Subacute Granulomatous Thyroiditis
Subacute Granulomatous Thyroiditis is aka.
(de Quervain)
- STUDY AID: Quer”vain” for “pain”
Histological finding of Subacute GRANULOMATOUS Thyroiditis (de Quervain)
Granulomatous Inflammation (resembles granulomas)
- Inflammatory infiltrate w/ macrophages and multinucleated giant cells
A self-limiting condition that can arise up to 1 year AFTER delivery and present as transient HYPERthyroidism –> HYPOthyroidism or vice versa; majority become euthyroid after resolution
Postpartum Thyroiditis
A condition when thyroid is replaced by FIBROUS tissue and inflammatory infiltrate due to IgG-related systemic disease; presents with a hard, PAINLESS goiter
Riedel Thyroiditis
The most common cause of goiter (enlarged thyroid) worldwide, not in US
Iodine deficiency
Drugs that interfere with the normal function of the thyroid gland (can cause both hypo- and hyperthyroidism) and can cause goiter by stimulating TSH
Goitrogens
- Amiodarone
- Lithium
The most common cause of hypoparathyroidism with resultant hypocalcemia
Complication of thyroidectomy due to inadvertent injury or removal of the parathyroid glands.
Post-operation hypocalcemia can be treated using
Ca+2 and vitamin D supplements
Spasm/contraction of facial muscles upon tapping of facial nerve of cheek due to hypocalcemia
Chvostek sign
*STUDY AID: Chvostek for “Cheek”
Carpal spasms when brachial artery (triceps) is occluded with BP cuff
Trousseau sign (백조 손모양)
- STUDY AID: Trousseau sign for “Triceps”
Lab findings of hypocalcemia and hyperphosphatemia due to low parathyroid hormone
Primary Hypoparathryodism
Thymic and parathyroid hypoplasia in DiGeorge syndrome results from maldevelopment of ___ and ____ pharyngeal/branchial pouches
- 3rd (inferior PT and thymus)
- 4th (superior PT)
Hypocalcemia can cause
- (Hypertension/Hypotension)
- neuromuscular (hyperexcitability/hypoexcitability)
- Hypotension
- hyperexcitability
- STUDY AID:
1. think about ca+2 blockers
2. muscle spasm (chevostek sign))
A hereditary condition with hypocalcemia due to kidneys and bones NOT responding to the actions of PTH; presents with short stature, round face, developmental delay
Pseudohypoparathyroidism (type 1 A)
Bone abnormality seen in Pseudohypoparathyroidism; aka. Albright Hereditary Osteodystrophy
shortened 4th/5th fingers
Lab findings of Pseudohypoparathyroidism
PTH, Ca+2, Phosphate
↑ PTH
↓ calcium
↑ phosphate
Mutation of what gene is responsible for causing Pseudohypoparathyroidism?
GNAS gene
A hereditary condition that has same physical findings as in Pseudohypoparathyroidism but has COMPLETELY NORMAL lab findings; caused by GNAS gene mutation WITHOUT end-organ resistance to PTH
Pseudopseudohypoparathyroidism
Lab findings of Pseudopseudohypoparathyroidism
PTH, Ca+2, Phosphate
ALL NORMAL!
Lab findings of hypercalcemia, hypercalciuria, hypophosphatemia, and high parathyroid hormone; usually due to parathyroid adenoma or hyperplasia
Primary Hyperparathyroidism
↑ bone resorption in Primary Hyperparathyroidism increases the risk of what bone disorder?
Osteoporosis
PULSATILE administration of _______ induces a greater ↑ in osteoblast activity in proportion to osteoclast activity and a net ↑ in bone formation; used as a tx for osteoporosis
Recombinant PTH analog (Teriparatide)
Clinical features/signs of hypercalcemia due to primary hyperparathyroidism
*STUDY AID: “stones, thrones, bones, groans, and psychiatric overtones”
- Stones: renal stones due to hypercalciuria
- Thrones: polyuria
- Bones: bone pain
- Groans: constipation
- Psychiatric Overtones: confusion, depression, memory loss, etc.
Cystic bone spaces filled with BROWN fibrous tissue causing bone pain in primary hyperparthyrodism due to increased bone turnover
Osteitis Fibrosa Cystica
Osteitis Fibrosa Cystica consists of osteoclasts and deposition of
hemosiderin (a protein that stores iron)
- why it looks brown
A disorder caused by defective Ca-sensing receptors in the parathyroid gland and kidneys which leads to excessive renal Ca+2 reabsorption –> Hypercalcemia, HYPOcalciuria, and normal/↑ PTH
Familial Hypocalciuric Hypercalcemia
Why is PTH level normal or ↑ in Familial Hypocalciuric Hypercalcemia?
Because it requires HIGHER than normal calcium level to suppress PTH
- body increases PTH thinking Ca+2 is not enough until it can finally sense with higher than normal Ca+2 level
Diuretic drug that can cause hypercalcaemia by ↑ the DCT reabsorption of Ca2+; lab findings include hypercalcemia and low PTH
Thiazides
↑ PTH due to ↓ Ca+2 absorption and/or ↑ phosphate level; most often caused by “chronic kidney disease” (can’t activate vitamin D, can’t reabsorb Ca+2 in kidney, and can’t excrete phosphate in kidney)
Secondary Hyperparathyroidism
- look for signs of CKD (↑ serum creatine or ↑ ALP)
Lab findings of Secondary Hyperparathyroidism
PTH, Ca+2, Phosphate
↑ PTH
↓ calcium
↑ phosphate