HIGH YIELD 1 Flashcards
this is not inherited, acute onset, decreased arch height with rocker bottom appearance
charcot neuropathy
inherited, slowly progressive, weakening peripheral muscles, children/adolescents, increased arch height, hammertoe contractures
charcot marie tooth
what can cause neuropathy?
syphilis
leprosy
RF for charcot?
h/o
duration
s/s
what is a diagnostic problem of charcot?
resemblance to osteomyelitis
- local inflammation
- delayed or missed diagnosis in 25% of cases
volkman/virchow responsible for this german theory of charcot?
neurotraumatic theory
jean martin charcot was responsible for this french theory of charcot?
neurovascular theory
main focus of the french neurovascular theory?
disregulation of arterial wall smooth muscle tone leads to increased blood flow to bone because of poor vasoregulation
main focus of the french neurotraumatic theory?
multiple traumas + joint instability/overload = deterioration of joint
development of charcot focuses on what aspects of neuropathy?
sensory/motor neuropathy and autonomic neuropathy
main causes of charcot?
unknown repetitive minor trauma surgery immunosuppresion metabolic insufficiencies
main cause of charcot?
unknown causes (74%)
trauma from repetitive stress (22-50%)
surgery (4%)
affect of trauma on non-DM charcot patient?
painful, stop WB, inflammation, decreases
affect of trauma on DM neuropathic patient patient?
nonpainful, lack of immobilization potentiates inflammatory processes
pro inflammatory and anti inflammatory cytokines?
TNFa to RANKL, IL-1B, IL-6
IL-4, IL-10