Hepatitis Flashcards
hepatitis E association
uncooked boar/swine/pig ingestion
HEV outbreaks are linked to
water contamination in Asia and Africa
treatment of chronic Hep E
ribavirin
treatment of chronic Hep E in pregnant women
none, can’t give them ribavirin
diagnosis of Hep E
RNA PCR
IgM anti HEV
most common cause of acute hepatitis in US
Hep A
fulminant hepatitis with chronic Hep C
hep A
when to use IG as post exposure ppx Hep A
> 40 years or immunosuppressed
when can you see liver tox from augmentin
often after stopping it
what type of genotype in HEV in US
Genotype 3
HCV association in which population
HIV MSM
blistering lesions in sun exposed areas, exacerbated by alcohol use
porphyria cutanea tarda
three skin manifestations of HCV
PCT
lichen Plans
cryoglobulin vasculitis
HBV skin manifestation
polyarteritis nodosa
HCV screening
one AB test aged 18 to 79 years
who needs HCV resistance testing treatment naive
Genotype 1a and using elbasvir/grazoprevir
Genotype 3 AND cirrhosis using sofosbuvir/velpatasvir
who needs HCV resistance testing treatment experienced
1a and using ledipasvir/sofosbuvir
Genotype 3 and using sofosbuvir/velpatasvir
Chronic HBV on treatment for HCV
If HBsAg positive
treat per HBV guidelines
Chronic HBV on treatment for HCV
Anti-HBc positive
monitor
pangenotypic HCV regimens
Glecaprevir/pibrentasvir
Sof/Vel
which HCV regimen is approved for ESRD
Glec/Pib
Sof/Vel
Sof/Led
which HCV regimen to avoid on patient taking darunavir
Glec/pib
(double protease inhibitors)
indication for treatment in HBsAg positive pregnant women
HBV DNA > 200,000 in third trimester
treatment HBV GFR <10 no HD
entecavir
Three situations for prophylaxis in CHB
Rituximab
high dose prednisone
BM transplant
Patients who are HBsAg positive undergoing immunosuppression
prophylaxis always needed no matter what immunosuppressive they get
If patient is anti-HBc positive but sAg negative when to given prophylaxis
rituximab, high dose prednisone or BM transplant (high risk exposures/IS)
isolated HBcore vaccination
give one dose, if titer >10 then stop
if titer <10 then give second dose
PEP for infants of HBsAg mothers
immediate vaccination and HBIG
