Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

IDBR > Anti Fungals > Flashcards

Anti Fungals Flashcards

1
Q

MOA of amphotericin

A

makes leaks in the cell membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

MOA of azoles

A

stop sterol synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

MOA of echinocandins

A

block cell wall synthesis (BD glucan)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

MOA of flucytosine

A

blocks DNA synthesis in the nucleus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

amphotericin resistant organisms

A

c. Lusitaniae
c. auris
aspergillus terreus
scedosporidium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Voriconazole concentration in CSF and urine

A

CSF good
urine none

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

formulation of Voriconazole to avoid in azotemia

A

IV form, oral is ok

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

long term side effect of voriconazole

A

periostitis
can see elevated alk phos

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

isavuconazole concentration in CSF and urine

A

none for both

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

two approved uses of posaconazole

A

prolonged neutropenia ppx
GVHD ppx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

side effects of posaconazole

A

hypertension
hypokalemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

fluconazole concentrations in CSF and urine

A

good in both

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

fluconazole does not have activity against which organisms

A

molds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

echinocandins concentration in CSF, urine, vitreous humor

A

poor
none
poor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

which anti fungal drug to not use in candidemia

A

isavuconazole
“not non inferior in study versus caspofungin”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

role of echinocandins in invasive aspergillosis

A

not recommended per IDSA

17
Q

three side effects of flucytosine

A

hepatitis
colitis
bone marrow suppression

18
Q

echinocandins have no effect against which organism

A

cryptococcus

19
Q

which 3 fungi is resistant to amphotericin B

A

scedosporium aspospermum
aspergillus terreus
candida Lusitaniae

20
Q

decreased azole level can be seen with which two drugs

A

phenytoin
rifampin

21
Q

which two fungi to not use echinocandins with

A

trichosporon
cryptococcus

22
Q

which candida species to not use fluconazole

A

krusei
auris
glabrata

23
Q

two treatment options for Scedosporium/Lomentospora spp

A

voriconazole or itraconazole

IDBR (23 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions