Anti Fungals Flashcards
MOA of amphotericin
makes leaks in the cell membrane
MOA of azoles
stop sterol synthesis
MOA of echinocandins
block cell wall synthesis (BD glucan)
MOA of flucytosine
blocks DNA synthesis in the nucleus
amphotericin resistant organisms
c. Lusitaniae
c. auris
aspergillus terreus
scedosporidium
Voriconazole concentration in CSF and urine
CSF good
urine none
formulation of Voriconazole to avoid in azotemia
IV form, oral is ok
long term side effect of voriconazole
periostitis
can see elevated alk phos
isavuconazole concentration in CSF and urine
none for both
two approved uses of posaconazole
prolonged neutropenia ppx
GVHD ppx
side effects of posaconazole
hypertension
hypokalemia
fluconazole concentrations in CSF and urine
good in both
fluconazole does not have activity against which organisms
molds
echinocandins concentration in CSF, urine, vitreous humor
poor
none
poor
which anti fungal drug to not use in candidemia
isavuconazole
“not non inferior in study versus caspofungin”
role of echinocandins in invasive aspergillosis
not recommended per IDSA
three side effects of flucytosine
hepatitis
colitis
bone marrow suppression
echinocandins have no effect against which organism
cryptococcus
which 3 fungi is resistant to amphotericin B
scedosporium aspospermum
aspergillus terreus
candida Lusitaniae
decreased azole level can be seen with which two drugs
phenytoin
rifampin
which two fungi to not use echinocandins with
trichosporon
cryptococcus
which candida species to not use fluconazole
krusei
auris
glabrata
two treatment options for Scedosporium/Lomentospora spp
voriconazole or itraconazole
