CMV, EBV, HHV-6, HHV-8

Question 1

non ID causes of mononucleosis with atypical lymphocytosis

Answer 1

drug hypersensitivity syndrome
(phenytoin, carbamazepine, INH, minocycline)

Question 2

when does EBV VCA IgM appear

Answer 2

0-8 weeks after infection

Question 3

when does EBV VCA IgG appear

Answer 3

2-4 weeks after infection

Question 4

when does EBV VCA IgG appear

Answer 4

2-4 weeks after infection

Question 5

when does EBV EBNA appear and how long does it last

Answer 5

2-4 months after infection, lasts the rest of persons life

Question 6

steps in treatment of PTLD

Answer 6

reduce IS
rituximab
chemotherapy

Question 7

high risk for CMV transmission organ

Answer 7

D+/R-

Question 8

high risk for CMV transmission SCT

Answer 8

D-/R+

Question 9

how to diagnose CMV mononucleosis syndrome

Answer 9

IgM to IgG seroconversion

Question 10

most common cause of non hereditary sensorineural hearing loss

Answer 10

congenital CMV

Question 11

CMV prophylaxis period

Answer 11

3-6 months after transplant

Question 12

preferred CMV prophylaxis in SCT

Answer 12

letermovir

Question 13

preferred CMV prophylaxis in SOT

Answer 13

valganciclovir

Question 14

duration of treatment for CMV

Answer 14

minimum of two weeks and CMV DNAemia below 200 on one or two consecutive weekly samples

Question 15

treatment of refractory/resistant CMV in SOT and SCT

Answer 15

maribavir

Question 16

CNS association with HHV-6

Answer 16

mesial temporal lobe epilepsy

Question 17

HHV-6 syndromes in IC

Answer 17

encephalitis
bone marrow suppression
pneumonitis

Question 18

HHV-6 encephalitis is most common in which population

Answer 18

allogeneic HCT recipients

Question 19

treatment of HHV-6 in IC

Answer 19

ganciclovir or foscarnet
cidofovir is last choice