Gram Negatives

Question 1

what drug to avoid with AMPC producing organisms

Answer 1

pip-tazo

Question 2

clinically relevant AMPC producing organisms

Answer 2

Klebsiella/Enterobacter aerogenes
E coli
Citrobacter freundii
Enterobacter cloacae

Question 3

empiric therapy for AMPC producing organisms

Answer 3

ceftolazone tazobactam
meropenem

Question 4

definition of difficult to treat PsA

Answer 4

R to cefepime, pip tazo, cetfazidime, aztreonam, cipro, levo, imi, mero

Question 5

best activity against difficult to treat PsA

Answer 5

ceftolazone-tazobactam

Question 6

which drug is inactivated by KPCs

Answer 6

ceftolazone-tazobactam

Question 7

which drug is protected against KPCs

Answer 7

avibactam (avycaz)

Question 8

cefiderocol has no activity against which two classes of organisms

Answer 8

Gram positive
anaerobes

Question 9

what three abx have the same side chain

Answer 9

cefiderocol
aztreonam
ceftazidime

Question 10

side effect of CTX

Answer 10

crystalizes in the biliary tree
pseudo cholelithiasis

Question 11

side effect of cefepime

Answer 11

non convulsive status epilepticus

Question 12

aztreonam has no activity against which class of organisms

Answer 12

gram positive

Question 13

moxifloxacin does not concentrate in

Answer 13

urine

Question 14

most common drug class to cause C diff

Answer 14

fluoroquinolone

Question 15

which FQ does not cause QTc prolongation

Answer 15

delafloxacin

Question 16

oral antibiotics for ESBL bacteria uncomplicated cystitis

Answer 16

fosfomycin
augmenting
nitrofurantoin

Question 17

bacteria with chromosomal AMPC

Answer 17

Kleb/enterobacter aerogenes
Enterobacter cloacae
Citrobacter freundii

Question 18

AMPC enzymes hydrolyze all cephalosporins except

Answer 18

ceftolozone/tazobactam
ceftazidime/avibactam
cefiderocol

Question 19

treatment against ESBL plus metallo-based carbapenamases

Answer 19

Ceftaz-avi plus aztreonam

Question 20

treatment against serine based carbapenamse KPC

Answer 20

ceftaz-avi
mero-vabor
imi-cilastatin-relebactam

Question 21

which FQ is preferred for pseudomonas treatment

Answer 21

ciprofloxacin

Question 22

what is the most common drug class to cause CDI

Answer 22

FQs

Question 23

risk of FQ plus NSAIDs

Answer 23

lowers seizure threshold

Question 24

mechanism of action of Aminoglycosides

Answer 24

binds to 30s ribosome, concentration dependent bactericidal activity

Question 25

most frequent method of AG resistance

Answer 25

enzymatic alteration of drug

Question 26

what is the only BLI with activity against acinetobacter

Answer 26

sulbactam