Gram Negatives Flashcards
what drug to avoid with AMPC producing organisms
pip-tazo
clinically relevant AMPC producing organisms
Klebsiella/Enterobacter aerogenes
E coli
Citrobacter freundii
Enterobacter cloacae
empiric therapy for AMPC producing organisms
ceftolazone tazobactam
meropenem
definition of difficult to treat PsA
R to cefepime, pip tazo, cetfazidime, aztreonam, cipro, levo, imi, mero
best activity against difficult to treat PsA
ceftolazone-tazobactam
which drug is inactivated by KPCs
ceftolazone-tazobactam
which drug is protected against KPCs
avibactam (avycaz)
cefiderocol has no activity against which two classes of organisms
Gram positive
anaerobes
what three abx have the same side chain
cefiderocol
aztreonam
ceftazidime
side effect of CTX
crystalizes in the biliary tree
pseudo cholelithiasis
side effect of cefepime
non convulsive status epilepticus
aztreonam has no activity against which class of organisms
gram positive
moxifloxacin does not concentrate in
urine
most common drug class to cause C diff
fluoroquinolone
which FQ does not cause QTc prolongation
delafloxacin
oral antibiotics for ESBL bacteria uncomplicated cystitis
fosfomycin
augmenting
nitrofurantoin
bacteria with chromosomal AMPC
Kleb/enterobacter aerogenes
Enterobacter cloacae
Citrobacter freundii
AMPC enzymes hydrolyze all cephalosporins except
ceftolozone/tazobactam
ceftazidime/avibactam
cefiderocol
treatment against ESBL plus metallo-based carbapenamases
Ceftaz-avi plus aztreonam
treatment against serine based carbapenamse KPC
ceftaz-avi
mero-vabor
imi-cilastatin-relebactam
which FQ is preferred for pseudomonas treatment
ciprofloxacin
what is the most common drug class to cause CDI
FQs
risk of FQ plus NSAIDs
lowers seizure threshold
mechanism of action of Aminoglycosides
binds to 30s ribosome, concentration dependent bactericidal activity
most frequent method of AG resistance
enzymatic alteration of drug
what is the only BLI with activity against acinetobacter
sulbactam
