Hematology Flashcards
Blood cancer associated with DIC
Acute Promyelocytic Leukemia
Microangiopathic Hemolytic Anemia + Thrombocytopenia
Thrombotic Thrombocytopenia Purpura
Livido Reticularis + Recurrent miscarriages
APLA Syndrome
Elderly with Blood Smear shows Lymphocytosis and Smudge cells
CLL
Normocytic Anemia with Sideroblastic change
Lead poisoning
Jaundice + cholecystitis + anemia
Hereditary Spherocytosis
Hodgkin Lymphoma with best prognosis
Lymphocyte predominant
Hodgkin Lymphoma with worst prognosis
Lymphocyte depleted
Malaria + Anemia + Increased reticulocyte count + Acute Kidney injury
Blackwater Fever
Best way to detect protein c deficiency
Copperhead Snake Venom Assay
Protein C inhibits which clotting factors
Factors Va and VIIIa
Early Pregnancy blood transfusion extra screening test
Cytomegalovirus
Pneumococcal vaccine before splenectomy time
Minimum 14 days before
Most common complication of heparin induced thrombocytopenia
Deep Vein Thrombosis
Excessive bleedingg following dental extraction
Von-Willebrand’s Disease
Cold Agglutinins + Lymphadenopathy + Night Sweats
Non- Hodgkin’s Lymphoma
Chemotherapy agents causing Neuropathy
- Vincristine
- Cisplatin
- Paclitaxel
What is Mycosis fungoides
Cutaneous T-Cell Lymphoma
Anemia + Hypercalcemia + Lower back pain
Multiple Myeloma
CLL with anemia investigation to identify cause
Antiglobulin Test (Coombs test)
Prophylactic to reduce bleed during procedures in von willebrand disease
DDAVP + Tranexamic Acid
Causative Agent of Aplastic Crisis in Sickle Cell Disease
Parvovirus B19
Autoantibodies responsible for Heparin-Induced Thrombocytopenia
Anti-heparin-PF4 antibodies.
Late complication of Hodgkin Lymphoma after chemo
Secondary Acute Myeloid Leukemia
Trephine biopsy showing fatty bone marrow
Aplastic Anemia
Aplastic Anemia management
Hematopoetic Stem Cell Transplantation
Most common type of Hodgkin’s Lymphoma
High Grade B cell Hodgkin’s Lymphoma
Neck Lump Investigation of choice
Excision Biopsy
Acute Myeloid Leukemia gene associated with worst prognosis
Chromosome 7 Abnormality
Medicine to reduce risk of acute urate nephropathy in AML
Allopurinol and Rasburicase
Nail finding Characteristic of Iron deficiency anemia
Koilonichya
First Line Treatment for Chronic Myeloid Leukemia
Imatinib
Drug of choice for DVT
Apixaban or Rivaroxaban
Urine Dipstick positive for blood + no red cell seen on urine microscopy
Paroxysmal Nocturnal Hemoglobinuria
Alteplase reversal Guidelines
FFP + Tranexamic Acid
Sickle Cell disease with Low Urine Osmolality
Nephrogenic Diabetes Insipidus
Leukemia + pancytopenia + LFT deranged + Diarrhea + Rash
Graft vs Host Disease
Nephrotic Syndrome clotting cause
- Protein S
- Anti Thrombin
Arthritis + Splenomegaly + Neutropenia
Felty’s Syndrome
Investigation to assess prognosis of Multiple Myeloma
Serum Beta-2 Microglobulin
Effective Management of Paroxysmal Nocturnal Hemoglobinuria
Eculizumab
Burkitt Lymphoma gene
c-Myc
Clinical Features of Primary Antiphospholipid syndrome
- DVT
- Livido Reticularis
- Thrombocytopenia
Anemia + Increased Osmotic Fragility
Hereditary Spherocytosis
Anemia + Cholecystitis
Hereditary Spherocytosis
Essential Thrombocytosis management
Hydroxycarbamide and Aspirin
Indication for Fresh Frozen Plasma Transfusion
Increased PT and APTT
Indication for Platelet Transfusion
Active Bleeding + Decreased Platelet <50,000
Heinz Body seen in
G6PD Deficiency
Evan’s Syndrome
Autoimmune Hemolytic Anemia and ITP
Inherited prothrombotic disorder in Northern Europe
Factor 5 leiden
Hairy Cell Leukemia gene affected
BRAF gene
Cells with abundant cytoplasm and broad based projections
Hairy Cell Leukemia
Acute Intermittent Porphyria Acute Attack management
IV Heme Arginate
How to differentiate Acute Intermittent Porphyria and Lead Poisoning
Anemia not seen in Acute Intermittent Porphyria
Monotherapy for CLL
Chlorambucil
Indication for Use of CEA in cancer patients
For Post op Surveillance
EBV Associated Lymphoma and Gene
Burkitt Lymphoma (c-Myc proto-oncogene)
Blood picture for Bone Mets cancer
Leukoerythroblastic blood picture
Cancer with Cachexia which acute phase marker is elevated
CRP
Common presentation of Ovarian cancer
Dermatomyositis (proximal muscle weakness) + bloating
Pregnancy with Hypercoagulability
Factor 5 Laiden mutation
Normal WBC but Smear shows bilobed nuclei in neutrophils
Pegler-Huet Syndrome
AML drug of choice to prevent Acute renal Impairment in Induction chemo
Rasburicase (urate oxidase)
Treatment of CLL Chemo regimen
Fludarabine, Cyclophosphamide and Rituximab (FCR)
Chemotherapy agent associated with Hypomagnesemia
Cisplatin
Highest risk of bacterial contamination when compared to other types of blood products
Platelet transfusions
Cancer with Anti-N-methyl D-aspartate (NMDA) Receptor Antibody +ve
Ovarian Teratoma
Investigation of choice for CLL
Immunophenotyping