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MRCP Part 1 > Clinical Pharmacology > Flashcards

Clinical Pharmacology Flashcards

1
Q

Drug with blue vision as complication

A

Sildenafil

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2
Q

Specific feature of Serotonin Syndrome

A

Myoclonus at the ankle

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3
Q

Management of Serotonin Syndrome

A

Cyproheptadine

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4
Q

Parkinson patient complaints of black urine

A

Effect on L-dopa

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5
Q

Receptor responsible for Trastuzumab causing cardiomyopathy

A

Erb-b2 Inhibition

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6
Q

Patient on TNF-Alpha therapy (Infliximab) now complaints of swollen lymph nodes

A

Lymphoma secondary to Immunomodulation therapy

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7
Q

Fungal infection of multiple nails of foot management

A

Oral Terbinafine

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8
Q

Tricyclic Antidepressant overdose management

A

Sodium Bicarbonate

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9
Q

Anti epileptic medication causing PCOS

A

Sodium Valproate

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10
Q

Electrolyte Imbalance seen with amphotericin B

A

Hypokalemia

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11
Q

Anti Tuberculosis medication causing failure of OCP

A

Rifampicin

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12
Q

Nabilone Mechanism of Action (Antiemetic)

A

Cannabinoid Receptor Stimulation

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13
Q

Chemotherapy agent with high risk of peripheral neuropathy

A

Vincristine

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14
Q

Sumatriptan Mechanism of Action

A

5HT1 agonist

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15
Q

Mechanism of action of Eculizumab

A

C5 Inhibitor

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16
Q

Specific side effect of COX-2 inhibitors (Celecoxib)

A

Sodium Retention

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17
Q

Recent Onset Metformin use and associated diarrhoea

A

Bile Salt Malabsorption

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18
Q

Anti hypertensive associated with constipation

A

Ca2+ Channel blocker - Diltiazem

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19
Q

Anti Tubercular medication causing decreased uric acid excretion

A

Pyrazinamide

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20
Q

Anti Epileptic associated with cerebellar toxicity

A

Carbamazepine

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21
Q

Carbamazepine dose needing to be increased soon after starting medication

A

Auto-Induction of Cytochrome

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22
Q

C. diff medication of choice if route is IV

A

Metronidazole

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23
Q

Meaning of bioequivalence

A

2 drugs have same pharmacokinetic and Pharmacodynamic effects

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24
Q

Acetazolamide most common side effect

A

Metabolic Acidosis, Hypokalemia and Acute Interstitial nephritis

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25
Q

Anti-emetic worsening torticollis

A

Prochlorperazine

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26
Q

Type of Calcium channels with effect on Heart

A

L-Type Calcium channel

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27
Q

Drug with greatest water solubility

A

Digoxin

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28
Q

Antibiotic associated with cholestati jaundice

A

Co-Amoxiclav

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29
Q

How to prevent tumor lysis syndrome

A

Allopurinol + Hydration before chemotherapy

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30
Q

Antibiotic associated with 6th CN Palsy and Intracranial Hypertension

A

Tetracycline

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31
Q

Terlipressin Hepatorenal syndrome MOA

A

Decrease Plasma Renin Activity

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32
Q

Dose of Vitamin D and Calcium in Osteoporosis per day

A

1500mg of Calcium and 400-800 units of vitamin D

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33
Q

Anti Psychotic with low risk of diabetes

A

Risperidone

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34
Q

Enzyme inhibited by Insulin

A

Pyruvate Carboxylase

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35
Q

Medicine causing greatest hazard during desensitization therapy

A

ACE Inhibitors

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36
Q

OHA to have a short term insulin release

A

Meglinitides (Repaglinide)

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37
Q

Antibiotic causing blue-grey skin pigmentation

A

Minocycline

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38
Q

Anti-Malarial avoided in G6PD Patients

A

Primaquine

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39
Q

DOC for Systemic Fungal Infection

A

Amphotericin

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40
Q

Ciclosporin MOA

A

IL-2 Inhibitor

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41
Q

MOA of Ondansetron

A

5HT3 Antagonist

42
Q

Complication of Iodine 131

A

May worsen graves ophthalmopathy for first 3 months

43
Q

Most effective strategy to reduce Hyperkalemia

A

10 units actrapid in 50mL 50% dextrose

44
Q

Drug used in Alzheimers for improving Cognition

A

Donepezil

45
Q

Initial management of Aspirin overdose

A

Activated Charcoal

46
Q

Cyanide Gas Antidote

A

Amyl Nitrate

47
Q

Accidental Injection of Adrenaline Management

A

Local Phentolamine

48
Q

Best way to diagnose Latent TB infection

A

Interferon gamma release assay

49
Q

Smoking patient has decreased response to paracetamol

A

Hepatic Enzyme induction

50
Q

Chemotherapy agent commonly causing SIADH

A

Vincristine

51
Q

Anti Tubercular drug causing peripheral neuropathy

A

Isoniazid

52
Q

Main enzyme responsible for Pioglitazone metabolism

A

CYP2C8

53
Q

Medicines causing acute dystonia as side effect

A

Metoclopramide and Prochlorperazine

54
Q

Stimulant drug with Hypokalemia as complication

A

Amphetamines

55
Q

Chemotherapy agent worsening Radiation toxicity

A

Dactinomycin
5-FU
Cisplatin

56
Q

Antibiotic causing pulmonary fibrosis

A

Nitrofurantoin

57
Q

MOA of Metformin

A

Activates AMP activated protein kinase

58
Q

Buserelin MOA

A

Inhibits androgen production

59
Q

Complication seen in Chronic Lead Poisoning

A

Peroneal Nerve Palsy

60
Q

How to differentiate Neuroleptic Malignant syndrome from Serotonin Syndrome

A

Hyperreflexia in Serotonin syndrome and Hyporeflexia in NMS

61
Q

Acute Cluster Headache management

A

Sumatriptan

62
Q

Anti Epileptic medication causing Dupyterens contracture

A

Phenytoin

63
Q

Antibiotic causing Orange-Red Urine

A

Rifampicin

64
Q

Bosentan MOA

A

Endothelin A and Receptor Antagonist

65
Q

Heart Failure medication causing gynecomastia

A

Digoxin

66
Q

Antiangina medication causing methemoglobinemia

A

Isosorbide Mononitrate

67
Q

Donepezil Side effect

A

Bradycardia

68
Q

Tactile hallucination seen in withdrawal of

A

Alcohol

69
Q

Antibiotic avoided in GBS

A

Ciprofloxacin (Worsen muscle weakness in GBS)

70
Q

HbA1c range for diabetics with hypoglycemic episodes

A

7%

71
Q

Heart Failure medication with great water solubility

A

Digoxin

72
Q

Antiepileptic with greatest risk of Congenital malformations

A

Sodium Valproate

73
Q

Aspirin Toxicity clinical features

A

Pale
Profuse sweating
Laboured Breathing - “Air Hunger”

74
Q

Most common side effect of ciclosporin

A

Hyperuricemia

75
Q

Antiepileptic drug causing pancreatitis

A

Sodium Valproate

76
Q

Carbon Monoxide ECG Finding

A

ST elevation in V4,V5,V6 in resting

77
Q

Most common medication causing Nephrogenic DI

A

Lithium

78
Q

Gabapentin Mechanism of Action

A

Alpha 2 subunit of voltage gated calcium channel

79
Q

Opioid induced constipation not relived with Senna

A

Sodium Docusate

80
Q

Site of Action of Nitrates

A

Large Veins

81
Q

Best way to determine 3D Structure of Protein

A

X-ray crystallography

82
Q

Beta Interferon Mechanism of Action

A

Increased MCH Class 1 expression

83
Q

Beta Interferon commonly used in

A

Multiple Sclerosis

84
Q

Alpha Interferon commonly used in

A

Hepatitis B and Hepatitis C

85
Q

Gut hormone stimulating Hunger

A

Ghrelin

86
Q

Bone formation marker used in Teriparatide monitoring

A

Procollagen Type 1 N Propeptide

87
Q

Blood test to confirm Ethylene Glycol poisoning

A

Hypocalcemia

88
Q

Bupropion Mechanism of Action

A

Noradrenaline Dopamine Reuptake Inhibitor

89
Q

Sudden Attacks of sleep in day time

A

Narcolepsy

90
Q

Waking up soon after sleep and unable to move limbs

A

Sleep Paralysis

91
Q

Most common side effect of Buspirone

A

Nasal Congestion

92
Q

Differentiate between Antisocial and Borderline personality disorder

A

BPD has self harm thro various methods in history

93
Q

Long term side effect of Lithium

A

Hypothyroidism

94
Q

Short term side effect of lithium

A

Fine Tremors

95
Q

Absolute Contra Indication for Electro convulsive Therapy

A

Raised Intra cranial pressure

96
Q

Anti psychotic causing Agranylocytosis

A

Clozapine

97
Q

Medicine to reduce alcohol craving

A

Naltrexone

98
Q

Small stature + Large Head + Large Jaw

A

Fragile X syndrome

99
Q

Management of Schizophrenia resistant to 2 antipsychotics

A

Clozapine

100
Q

Antidepressant used in patients on Warfarin

A

Mirtazapine

101
Q

Test to predict Steven Johnson Syndrome

A

HLA Type

MRCP Part 1 (17 decks)

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