Clinical Pharmacology Flashcards by Amal Joseph

Drug with blue vision as complication

Sildenafil

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Specific feature of Serotonin Syndrome

Myoclonus at the ankle

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Management of Serotonin Syndrome

Cyproheptadine

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Parkinson patient complaints of black urine

Effect on L-dopa

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Receptor responsible for Trastuzumab causing cardiomyopathy

Erb-b2 Inhibition

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Patient on TNF-Alpha therapy (Infliximab) now complaints of swollen lymph nodes

Lymphoma secondary to Immunomodulation therapy

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Fungal infection of multiple nails of foot management

Oral Terbinafine

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Tricyclic Antidepressant overdose management

Sodium Bicarbonate

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Anti epileptic medication causing PCOS

Sodium Valproate

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Electrolyte Imbalance seen with amphotericin B

Hypokalemia

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Anti Tuberculosis medication causing failure of OCP

Rifampicin

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Nabilone Mechanism of Action (Antiemetic)

Cannabinoid Receptor Stimulation

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Chemotherapy agent with high risk of peripheral neuropathy

Vincristine

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Sumatriptan Mechanism of Action

5HT1 agonist

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Mechanism of action of Eculizumab

C5 Inhibitor

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Specific side effect of COX-2 inhibitors (Celecoxib)

Sodium Retention

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Recent Onset Metformin use and associated diarrhoea

Bile Salt Malabsorption

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Anti hypertensive associated with constipation

Ca2+ Channel blocker - Diltiazem

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Anti Tubercular medication causing decreased uric acid excretion

Pyrazinamide

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Anti Epileptic associated with cerebellar toxicity

Carbamazepine

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Carbamazepine dose needing to be increased soon after starting medication

Auto-Induction of Cytochrome

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C. diff medication of choice if route is IV

Metronidazole

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Meaning of bioequivalence

2 drugs have same pharmacokinetic and Pharmacodynamic effects

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Acetazolamide most common side effect

Metabolic Acidosis, Hypokalemia and Acute Interstitial nephritis

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Anti-emetic worsening torticollis

Prochlorperazine

Type of Calcium channels with effect on Heart

L-Type Calcium channel

Drug with greatest water solubility

Digoxin

Antibiotic associated with cholestati jaundice

Co-Amoxiclav

How to prevent tumor lysis syndrome

Allopurinol + Hydration before chemotherapy

Antibiotic associated with 6th CN Palsy and Intracranial Hypertension

Tetracycline

Terlipressin Hepatorenal syndrome MOA

Decrease Plasma Renin Activity

Dose of Vitamin D and Calcium in Osteoporosis per day

1500mg of Calcium and 400-800 units of vitamin D

Anti Psychotic with low risk of diabetes

Risperidone

Enzyme inhibited by Insulin

Pyruvate Carboxylase

Medicine causing greatest hazard during desensitization therapy

ACE Inhibitors

OHA to have a short term insulin release

Meglinitides (Repaglinide)

Antibiotic causing blue-grey skin pigmentation

Minocycline

Anti-Malarial avoided in G6PD Patients

Primaquine

DOC for Systemic Fungal Infection

Amphotericin

Ciclosporin MOA

IL-2 Inhibitor

MOA of Ondansetron

5HT3 Antagonist

Complication of Iodine 131

May worsen graves ophthalmopathy for first 3 months

Most effective strategy to reduce Hyperkalemia

10 units actrapid in 50mL 50% dextrose

Drug used in Alzheimers for improving Cognition

Donepezil

Initial management of Aspirin overdose

Activated Charcoal

Cyanide Gas Antidote

Amyl Nitrate

Accidental Injection of Adrenaline Management

Local Phentolamine

Best way to diagnose Latent TB infection

Interferon gamma release assay

Smoking patient has decreased response to paracetamol

Hepatic Enzyme induction

Chemotherapy agent commonly causing SIADH

Vincristine

Anti Tubercular drug causing peripheral neuropathy

Isoniazid

Main enzyme responsible for Pioglitazone metabolism

CYP2C8

Medicines causing acute dystonia as side effect

Metoclopramide and Prochlorperazine

Stimulant drug with Hypokalemia as complication

Amphetamines

Chemotherapy agent worsening Radiation toxicity

Dactinomycin 5-FU Cisplatin

Antibiotic causing pulmonary fibrosis

Nitrofurantoin

MOA of Metformin

Activates AMP activated protein kinase

Buserelin MOA

Inhibits androgen production

Complication seen in Chronic Lead Poisoning

Peroneal Nerve Palsy

How to differentiate Neuroleptic Malignant syndrome from Serotonin Syndrome

Hyperreflexia in Serotonin syndrome and Hyporeflexia in NMS

Acute Cluster Headache management

Sumatriptan

Anti Epileptic medication causing Dupyterens contracture

Phenytoin

Antibiotic causing Orange-Red Urine

Rifampicin

Bosentan MOA

Endothelin B and A Receptor Antagonist

Heart Failure medication causing gynecomastia

Digoxin

Antiangina medication causing methemoglobinemia

Isosorbide Mononitrate

Donepezil Side effect

Bradycardia

Tactile hallucination seen in withdrawal of

Alcohol

Antibiotic avoided in GBS

Ciprofloxacin (Worsen muscle weakness in GBS)

HbA1c range for diabetics with hypoglycemic episodes

Heart Failure medication with great water solubility

Digoxin

Antiepileptic with greatest risk of Congenital malformations

Sodium Valproate

Aspirin Toxicity clinical features

Pale Profuse sweating Laboured Breathing - "Air Hunger"

Most common side effect of ciclosporin

Hyperuricemia

Antiepileptic drug causing pancreatitis

Sodium Valproate

Carbon Monoxide ECG Finding

ST elevation in V4,V5,V6 in resting

Most common medication causing Nephrogenic DI

Lithium

Gabapentin Mechanism of Action

Alpha 2 subunit of voltage gated calcium channel

Opioid induced constipation not relived with Senna

Sodium Docusate

Site of Action of Nitrates

Large Veins

Best way to determine 3D Structure of Protein

X-ray crystallography

Beta Interferon Mechanism of Action

Increased MCH Class 1 expression

Beta Interferon commonly used in

Multiple Sclerosis

Alpha Interferon commonly used in

Hepatitis B and Hepatitis C

Gut hormone stimulating Hunger

Ghrelin

Bone formation marker used in Teriparatide monitoring

Procollagen Type 1 N Propeptide

Blood test to confirm Ethylene Glycol poisoning

Hypocalcemia

Bupropion Mechanism of Action

Noradrenaline Dopamine Reuptake Inhibitor

Sudden Attacks of sleep in day time

Narcolepsy

Waking up soon after sleep and unable to move limbs

Sleep Paralysis

Most common side effect of Buspirone

Nasal Congestion

Differentiate between Antisocial and Borderline personality disorder

BPD has self harm thro various methods in history

Long term side effect of Lithium

Hypothyroidism

Short term side effect of lithium

Fine Tremors

Absolute Contra Indication for Electro convulsive Therapy

Raised Intra cranial pressure

Anti psychotic causing Agranylocytosis

Clozapine

Medicine to reduce alcohol craving

Naltrexone

Small stature + Large Head + Large Jaw

Fragile X syndrome

Management of Schizophrenia resistant to 2 antipsychotics

Clozapine

Antidepressant used in patients on Warfarin

Mirtazapine

Test to predict Steven Johnson Syndrome

HLA Type

Cancers in Male prevented by HPV Vaccine

- Oral - Oropharyngeal - Penile

Management of Oculogenic Crisis

- Procyclidine - Benztropine

Common medication causing Peripheral edema

PAD Pregabalin Amlodipine Doxazocin

Common medication causing Peripheral edema

PAD Pregabalin Amlodipine Doxazocin

Common medication causing Peripheral edema

PAD Pregabalin Amlodipine Doxazocin

Baclofen Mechanism of Action

GABA-B Agonist

Local anesthetic toxicity management

IV 20% lipid emulsion

Pilocarpine MOA

Muscarinic Agonist

Factor Xa Inhibitor (Apixaban, Rivaroxaban) Antidote

Andexanet alfa

Dabigatran Antidote

Idarucizumab

Safer opioid End-stage renal failure

Oxycodone

Most Important HLA matching in Renal transplant

HLA-DR

Treatment for Homocystinuria

Pyridoxine

Management of Restless leg syndrome

Ropinirole (Dopamine agonist)

Which receptor does nicotine bind to

Acetylcholine Receptor

Clinical Pharmacology Flashcards

(116 cards)