Hema (AML with genetic abnormalities)

Question 1

AML with t(8;21) (q22;q22) is ______% of AML cases

Answer 1

5-10%

Question 2

AML genetic abnormality predominant in younger patients

Answer 2

AML with t(8;21) (q22;q22)

AML with inv (16) (p13q22) or t(16;16) (p13;q22)

Question 3

AML with inv (16) (p13q22) or t(16;16) (p13;q22) is ________ % of AML cases

Answer 3

10%

Question 4

AML with t(15;17) (q22;q12) or acute promyelocytic leukemia
is _______% of AML cases

Answer 4

5%

Question 5

AML with 11q23 abnormalities are ________% of AML cases

Answer 5

5%

Question 6

AML with genetic abnormality occurring at any age but more common in CHILDREN

Answer 6

AML with 11q23 abnormalities

Question 7

Has Blasts – typically
large, with abundant
basophilic cytoplasm, often with Auer rods and numerous, sometimes very large azurophilic granules

Answer 7

AML with t(8;21)
(q22;q22)

Question 8

Bone marrow usually has elements of both granulocytic and monocytic differentiation combined with abnormal eosinophils

Answer 8

AML with inv (16)
(p13q22) or
t(16;16) (p13;q22)

Question 9

Eosinophil precursors contain abnormally large, purple granules
that can be sufficiently
numerous to obscure the nuclei

Answer 9

AML with inv (16)
(p13q22) or
t(16;16) (p13;q22)

Question 10

Abnormal promyelocytes are present, either hypergranular or hypogranular (microgranular)

Answer 10

AML with t(15;17) (q22;q12)
or acute promyelocytic
leukemia

Question 11

In the hypergranular form,
the cytoplasm is packed with
pink, red, or purple granules
that are usually large, but
may be fine.

Answer 11

AML with t(15;17) (q22;q12)
or acute promyelocytic
leukemia

Question 12

Bundles of Auer rods are
present in most cases; the
nuclei, which may be bilobed,
are irregular in size and
variable in shape and maybe
reniform (kidney-shaped)

Answer 12

AML with t(15;17) (q22;q12)
or acute promyelocytic
leukemia

Question 13

most common morphologic pattern of AML with 11q23 abnormalities

Answer 13

Monocytic differentiation, with monoblasts and promonocytes
predominating

Question 14

Patients may have gum
infiltration, and DIC

Answer 14

AML with 11q23
abnormalities

Question 15

In 11q23, these are large
cells with round nuclei
that usually contain lacy
chromatin and large
prominent nucleoli

Answer 15

Monoblasts

Question 16

Abundant basophilic
and sometimes
vacuolated cytoplasm
may form pseudopods
and contain scattered,
fine azurophilic
granules.

Answer 16

11q23

Question 17

t(8;21) in FAB

Answer 17

AML M2

Question 18

t(15;17) in FAB

Answer 18

AML M3

Question 19

t(16;16) in FAB

Answer 19

AML M4

Question 20

t(9;11) in FAB

Answer 20

M5a

Question 21

t(8;16) in FAB

Answer 21

M5b

Question 22

t(1;22) in FAB

Answer 22

AML M7

Question 23

t(9;22) –> BCR/ABL in FAB

Answer 23

CML

Question 24

t(8;14) –> MYC in FAB

Answer 24

Burkitt

Question 25

JAK2

Answer 25

PV

Question 26

t(11;14)

Answer 26

MM

Question 27

t(12;21)

Answer 27

ALL

Question 28

An aspirate with a dual population of small and large blasts with prominent eosinophilia

Answer 28

AMML WITH INV16

Question 29

Some of the cells include the “eosinobasophils,”

Answer 29

AMML WITH INV16

Question 30

Biopsy shows hypercellular marrow with monocytic blasts and eosinophilia. Note the large monocytic blasts with folded nuclear contours.

Answer 30

AMML WITH INV16

Question 31

unusual “blob-like” Auer rods

Answer 31

Pseudo-Chediak Higashi inclusion

Question 32

Pseudo-Chediak Higashi inclusion is associated with

Answer 32

t(8;21) or M2

Question 33

FAB L3/Burkitt lymphoma

Answer 33

t(8;14)

Question 34

Pre-B cell ALL

Answer 34

t(19;22)

Question 35

B cell ALL

Answer 35

t(4;11)

Question 36

T cell ALL

Answer 36

t(7;11)