Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MTAP 2 > Hema (AML M0-M7) > Flashcards

Hema (AML M0-M7) Flashcards

1
Q

Undifferentiated blasts in BM and PBS, AML—not otherwise categorized

A

AML Undifferentiated/Minimally Differentiated (M0)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

30% blast cells – indistinguishable

A

AML Undifferentiated/Minimally Differentiated (M0)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

% blast cells in M0
as indistinguishable

A

30%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

M0 constitutes ___ of AML

A

5%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Age group for M0

A

Adults

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

blasts show no myeloid differentiation
medium-sized, have an agranular basophilic cytoplasm, round or slightly indented nuclei with 1 or 2 nucleoli, and dispersed chromatin

A

AML Undifferentiated/Minimally Differentiated (M0)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

<3% of blasts react to Sudan black, a-naphthyl acetate, or stains that
detects myeloperoxidase

A

AML Undifferentiated/Minimally Differentiated (M0)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

M1 constitutes ___% of AML

A

10%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Age group for M1

A

Adults

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Azurophilic granules and Auer rods in the cytoplasm of the blast may suggest their myeloid nature

A

AML Differentiated without maturation (M1)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

In other cases, the blasts resemble lymphoblasts, from which they are differentiated by positivity to myeloperoxidase stains or Sudan black in at least 3% of blast cells

A

AML Differentiated without maturation (M1)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

M2 constitutes ___% of AML

A

30-45%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Age group for M2

A

ALL ages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Blasts may show azurophilic granules and Auer rods, and evidence of maturation is present

A

AML with maturation (M2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

> 10% of marrow cells being promyelocytes, myelocytes, and mature neutrophils

A

AML with maturation (M2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

In M2, >10% of marrow cells are

A

promyelocytes,
myelocytes,
mature neutrophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

In M2, <20% of marrow cells are

A

monocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

< 20% being monocytes

A

AML with maturation (M2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Neutrophils may show abnormally increased or decreased segmentation and lobulation

Basophils, eosinophils, and mast cells may be increased

A

AML with maturation (M2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Highest number of Auer rods, collectively named as Faggot cells/Firewood cells (bundles)

A

AML Promyelomonocytic (M3)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

30% blasts, >10% granulocytic lineage and >10% Promyelocytes

A

AML Promyelomonocytic (M3)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

% blasts in M3

A

30%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

> 10% in M3 are

A

granulocytic lineage
promyelocytes

24
Q

Associated with chromosomal translocation of 15:17 (WHO)

A

AML Promyelomonocytic (M3)

25
Q

Increased incidence of Disseminated Intravascular Coagulation (DIC)

A

AML Promyelomonocytic (M3)

26
Q

aka Acute myelomonocytic leukemia/

A

Naegeli Biphasic M1 & M5

27
Q

M4 constitutes ___% of AML

A

15-25%

28
Q

Age group for M4

A

Elderly

29
Q

Sometimes in patients preceding chronic myelomonocytic leukemia (CMML)

A

Acute myelomonocytic leukemia/ Naegeli Biphasic M1 & M5 (M4)

30
Q

Indicator are monoblasts and promonocytes

A

Acute myelomonocytic leukemia/ Naegeli Biphasic M1 & M5 (M4)

31
Q

In M4, these are large cells with round containing >1 prominent nuclei and abundant basophilic
cytoplasm, sometimes with fine azurophilic granules, vacuoles, and pseudopods formation

A

Monoblasts

32
Q

In M4, these are less basophilic and more granulated cytoplasm, containing occasional
vacuoles, and azurophilic granules

A

Promonocytes

33
Q

Irregular and indented nucleus

A

Acute myelomonocytic leukemia/ Naegeli Biphasic M1 & M5 (M4)

34
Q

M5 constitutes ___% of AML

A

5% each type

35
Q

M5 more common in children (<17 y/o)

A

M5a

36
Q

M5 more common in adults (>18 y/o)

A

M5b

37
Q

at least 80% of the leukemic cells are in the monocytic line

A

Acute monoblastic and acute monocytic leukemia (M5a, M5b)

38
Q

at least 80% of the monocytic cells are monoblasts

A

acute monoblastic leukemia (M5a)

39
Q

most of them are promonocytes

A

acute monocytic leukemia (M5b)

40
Q

Acute erythroid leukemia subtypes

A

Erythroleukemia (erythroid/myeloid) – M6a

Pure erythroid leukemia – M6b

41
Q

M6a constitutes ___% of AML

A

5%

42
Q

In M6a, 50% of the nucleated cells in the bone marrow is

A

ERYTHROID

43
Q

In M6a, these are dysplastic, containing multiple and megaloblastoid nuclei, the cytoplasm often
possessing poorly delineated, coalescing vacuoles

A

erythroid (50%)

44
Q

In M6a, 20% of nonerythroid cells are

A

myeloblast

45
Q

In M6a, these are similar to those in AML with
and without maturation

A

myeloblast

46
Q

Very rare type of M6

A

M6b

47
Q

In M6b, >80% of the marrow cells are

A

erythroid

48
Q

Erythroblast in this type have deeply basophilic, often agranular, cytoplasm that may contain poorly
delineated vacuoles

Round nuclei have fine chromatin and >1 nuclei

A

Pure erythroid leukemia – M6b

49
Q

M7 constitutes ___% of AML

A

5%

50
Q

Age group for M7

A

ALL ages

51
Q

In M7, 50% of the blast are from

A

megakaryocyte lineage

52
Q

Often pleomorphic and have a basophilic, often agranular cytoplasm, cytoplasm may demonstrate pseudopod and bleb formation, indicating budding platelets in M7; Nuclei have fine chromatin and 1-3 nucleoli

A

Megakaryoblasts

53
Q

In M7, these may be visible in the blood, as may be circulating micromegakaryocytes and megakaryocyte fragments

A

Dysplastic platelets

54
Q

aka Schilling type

A

M5

55
Q

aka Erythemic myelosis or Di Guglielmo syndrome

A

M6

56
Q

aka MDS with excess blasts

A

M6

MTAP 2 (23 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions