Heart Failure Flashcards
Describe Frank Starling’s Law.
Pressure is proportional to SV.
increase EDV = increase PRELOAD = increase SV = increase CONTRACTILITY
Presentations of Left Heart Failure
[PERIPHERAL CONGESTION]
- Peripheral edema (increase in abd. girth)
- LOC, fatigue (ischemia)
- Impaired liver fx (liver congestion)
- End organ failure/anorexia, weight loss, GI distress (GI congestion)
Presentations of Right heart failure
- Decreased CO
- Activity intolerance + Hypoxemia (low perfusion) - Impaired gas exchange
- Cyanosis/Hypoxia (impaired gas exchange) - Pulmonary edema
- Orthopnea
- Paroxysmal nocturnal dyspnea
- Wet cough
What is orthopnea?
Breathlessness when laying down.
- Sx: LS heart failure
Paroxysmal nocturnal dyspnea
SOB that awakens a person
- Sx: LS heart failure
Inotropy
Medications that alter heart’s contractility
What is the focus of tx for HF?
- Decrease cardiac workload + increase O2 supply
2. Increase contractility
Cardiac Glycosides
- MOA? (2)
- Tx for _____?
- Common medications
- Contraindications?
MOA: Affects overall electrolyte transport across cell membrane
- Blocks NA/ATPase = high NA-Ca exchange in cell = increased contractility
- Slow electrical conduction @ AV node = lowers HR + increases CO
Tx:
- Chronic HF
- Arrhythmias
Common drugs:
- Digoxin (Lanoxin), Digitoxin
Contraindications:
- Apical pulse for 1 min <60bpm = HOLD
- Antidote for toxicity: DIGIBIND (1st sign is N+V)
Digitalization
The loading dose of cardiac glycosides
P-Inhibitors
- MOA?
- Tx for ____?
Block phosphodiesterase (PDE) = increases cAMP
- Increases contractility of myocardial cells
- Vasodilation/relaxation of smooth muscle cells
Tx: Acute HF
What drug class does Viagra belong to?
P-Inhibitor
- Increase BF to genitals = erection
Milrinone, Amrinone
Drug class?
What is it used to treat?
P-Inhibitors
Tx: Acute HF
Adrenergic Agonists
- What is the MOA?
- Tx for _____?
MOA (mimic catecholamines)
- Increases contractility
- Increases CO
- Vasodilation
Tx: Acute HF
What drug class does "Dobutamine" belong to? - Tx for \_\_\_\_\_\_?
Adrenergic Agonists: direct sympathomimetic (beta-1 specific)
Tx: Acute HF
What drug class does "Dopamine HCL" belong to? - Tx for \_\_\_\_\_\_?
Adrenergic Agonists: non-selective beta (precursor to Norepi)
Tx: Acute HF