DRUUUUUUGS Flashcards
Toxicities: Cholinergics vs Anticholinergics
Cholinergics = “SLUDGE”
= Salivation, Lacrimation, Urination, Diaphoresis, GI distress, Emesis
Anticholinergics - think about normal fxs but excessive
= Increased IOP** + blindness, Urinary retention, Flushed skin, Altered LOC**
Antidote to Benzodiazepine
Flumazenil
Antidote to Barbituates
Activated charcoal, NaHCO3, Megimide
Antidote to opioids
Naloxone
Anticonvulsant toxicities
Nausea, Nystagmus, Ataxia
- Barbituates
- Benzos
- Phenytoins
Serotonin agonists like SumaTRIPTAN - contraindications?
Drug is for migraines
DO NOT GIVE to pts with uncontrolled HTN / CAD because it constricts cranial BVs
Ibuprofen + kids
Never give to kids UNDER 6 MONTHS
Antidote of Digoxin
Digibind
Tx Bradycardia
Atropine
Tx SVT
Adenosine
Thrombolytic therapy
Must be given within 4.5 hrs of Stoke Sxs onset!
Contraindications
= Active bleed/Hemorrhage
= Recent brain/spine surgery
= Low platelets or High INR/PT
= Uncontrollable HTN (>185/110)
Seldenafil and the other “-fils”
- Contraindications?
“-fils” for BPH/Erectile dysfunction - VASODILATORY effect
S/e = Blue discoloration of vision + Priapism (painful erection for > 6 hrs)
DO NOT TAKE WITH:
= Alpha Adrenergic antagonists (“-zosin”)
= Angina (within 24-48 hrs of Nitrate)
2 drugs that helps with BPH + their fxs
- Alpha receptor blockers (TamsulOSIN, DoxazOSIN) - relaxes prostate muscle + bladder neck
= orthostatic hypotension - Alpha Reductase inhibitor (FINASTRIDE) - reduces prostate size (hormonally)
What decreases the effectiveness of birth control pills/oral contraceptives?
Abx, Anticonvulsants, Antivirals
Clomiphene
Reproductive drug - Stimulates ovulation in infertile females
Biphosphonates
- Considerations of admin?
For Osteoporosis (decreases bone resorption/breakdown)
- Take on empty stomach / 30 minutes before other drugs
- Full glass of water
- Upright for 30 mins to help w/ absorption + minimize esophageal irritation
Metronidazole
Abx for Trichomoniasis + Bacterial vaginosis
Expected s/e = dark urine
Magnesium Sulfate
= Neuro protection for premature babies (Cerebral palsy)
= Seizure prophylaxis in PREECLAMPSIA mothers
Lithium
- Therapeutic/Toxic levels
- Toxic Sxs
- What to do?
Mood stabilizer (Mania, with Valproic acid)
Therapeutic level = 0.8-1.2
Toxic = over 2 + tremors
NO low Na intake