DRUUUUUUGS

Question 1

Toxicities: Cholinergics vs Anticholinergics

Answer 1

Cholinergics = “SLUDGE”
= Salivation, Lacrimation, Urination, Diaphoresis, GI distress, Emesis

Anticholinergics - think about normal fxs but excessive
= Increased IOP** + blindness, Urinary retention, Flushed skin, Altered LOC**

Question 2

Antidote to Benzodiazepine

Answer 2

Flumazenil

Question 3

Antidote to Barbituates

Answer 3

Activated charcoal, NaHCO3, Megimide

Question 4

Antidote to opioids

Answer 4

Naloxone

Question 5

Anticonvulsant toxicities

Answer 5

Nausea, Nystagmus, Ataxia

• Barbituates
• Benzos
• Phenytoins

Question 6

Serotonin agonists like SumaTRIPTAN - contraindications?

Answer 6

Drug is for migraines

DO NOT GIVE to pts with uncontrolled HTN / CAD because it constricts cranial BVs

Question 7

Ibuprofen + kids

Answer 7

Never give to kids UNDER 6 MONTHS

Question 8

Antidote of Digoxin

Answer 8

Digibind

Question 9

Tx Bradycardia

Answer 9

Atropine

Question 10

Tx SVT

Answer 10

Adenosine

Question 11

Thrombolytic therapy

Answer 11

Must be given within 4.5 hrs of Stoke Sxs onset!

Contraindications
= Active bleed/Hemorrhage
= Recent brain/spine surgery
= Low platelets or High INR/PT
= Uncontrollable HTN (>185/110)

Question 12

Seldenafil and the other “-fils”
- Contraindications?

Answer 12

“-fils” for BPH/Erectile dysfunction - VASODILATORY effect
S/e = Blue discoloration of vision + Priapism (painful erection for > 6 hrs)

DO NOT TAKE WITH:
= Alpha Adrenergic antagonists (“-zosin”)
= Angina (within 24-48 hrs of Nitrate)

Question 13

2 drugs that helps with BPH + their fxs

Answer 13

1. Alpha receptor blockers (TamsulOSIN, DoxazOSIN) - relaxes prostate muscle + bladder neck
   = orthostatic hypotension
2. Alpha Reductase inhibitor (FINASTRIDE) - reduces prostate size (hormonally)

Question 14

What decreases the effectiveness of birth control pills/oral contraceptives?

Answer 14

Abx, Anticonvulsants, Antivirals

Question 15

Clomiphene

Answer 15

Reproductive drug - Stimulates ovulation in infertile females

Question 16

Biphosphonates
- Considerations of admin?

Answer 16

For Osteoporosis (decreases bone resorption/breakdown)

• Take on empty stomach / 30 minutes before other drugs
• Full glass of water
• Upright for 30 mins to help w/ absorption + minimize esophageal irritation

Question 17

Metronidazole

Answer 17

Abx for Trichomoniasis + Bacterial vaginosis

Expected s/e = dark urine

Question 18

Magnesium Sulfate

Answer 18

= Neuro protection for premature babies (Cerebral palsy)
= Seizure prophylaxis in PREECLAMPSIA mothers

Question 19

Lithium
- Therapeutic/Toxic levels
- Toxic Sxs
- What to do?

Answer 19

Mood stabilizer (Mania, with Valproic acid)
Therapeutic level = 0.8-1.2
Toxic = over 2 + tremors

NO low Na intake