Heart disease Biomarkers Flashcards
what can be used in the heart as a biomarker?
myoglobin
lactase dehydrogenase
creatine kianse
troponin`
myoglobin
haem containing oygen binding prtein
meets short term needs ofoxygen
myoglobin is released into the blood when there is muscle cell injury
how quickly is myogloin releaased into the blood stream after injury?
2-6 hrs after injury with peak levels areound 8-12hrs after
what is LDh
lactase dehydrogenase
take pyruvate and converts to lactase diving NAD and NADH
role of LDH
intracellualr enzyme found in heart, liver, skeletal muscle and kidney
released on dmage to cells 12 hrs after injury
role of creatine kinase
intracellulra enzyme found in heart, skeletal muscle and breain
released in cellular damage 3-6 hrs after injury
- converts creatine into creatine phosphate for energy quickly
three types of troponin
T: binsd tropomyosin
I: binds actin filaments inhibiting contraction
C: binds calcium causing contraction
role of troponin
released on muscular damage into circulation 3-6 hrs after
how can we determine these indicators arent from other muscles around the body and are from the heart?
isoforms!
which isoform of creatine kinse is the hart one
CK-BM
which isoform of LHD is the heart one
LHD1
cardica forms of troponin
TnI
TnT
what other diseasesmight result in high troponin levels?
pericarditis renal failure heart failure pulmonary embolism septic shock rhamdomylosis stroke liver cirrhosis
NICE guidelines fr heart attack diagnosis
increase in cardiac marker: - ischaemic symptoms pathological Q waves -ECG changes - sometimes ST segement elevated
high troponin
doesnt always mean MI
can be associated with other diseases and conditions
