Head and Neck Flashcards
benign lesion of HPV origin, most commonly type 6/11 with exophytic, finger-like projectionsindic
papilloma
premalignant lesion that is white plaque like
leukoplakia
95% of head and neck malignancies
squamous cell carcinoma
80% of these harbor oncogenic variants of HPV
squamous cell carcinoma
most commonly on the hard palate or gingiva
mucosal melanoma
most SCC occur on these 2 locations
-floor of mouth
-lateral/ventral surfaces of tongue
for a shave/mucosal biopsy, what is it important to do
maintain orientation of the mucosa
if there is suspicion of bone invasion, what should be done
radiograph the specimen
if IHCs need to be performed for a specimen with bone, what must you make sure to do
make sure the appropriate decal is used
staging oral cavity or tongue is largely dependent on these two things
tumor size and depth of invasion
measurement from the horizon of basement membrane of the adjacent uninvolved mucosa perpendicularly to the deepest point of invasion
depth of invasion
measured from the surface of the invasive SCC for an endophytic/exophytic tumor, and from the ulcer base for an ulcerated tumor to the deepest point of invasion
tumor thickness
anterior thyroid is what shape
convex
posterior thyroid is what shape
concave
types of thyroid specimens you can receive (3)
-FNA
-hemi-thyroidectomy
-Thyroidectomy
gross appearance is diffusely enlarged, pale yellow-tan, with a firm nodular cut surface
Hashimoto’s thyroiditis
recurrent episodes of hyperplasia and involution
multinodular goiter
caused by insufficient iodine, with gradual thyroid failure due to autoimmune destruction of the gland
Hashimoto’s thyroiditis
thyroid enlargement with over 2000 g possible
multinodular goiter
normal weight of thyroid
18-25 g
gross cut section bulges from the cut surface, solitary spherical and encapsulated
follicular adenoma (of thyroid)
gross appearance of well circumscribed, encapsulated with a friable, papillary surface
papillary carcinoma
gross appearance of capsular invasion, multilobulated tan-yellow to pink, solid to cystic
follicular carcinoma
neuroendocrine origin, well circumscribed, may contain central coarse/microcalcifications ranging from gray-white to yellow-brown
medullary carcinoma