Haemtology

Question 1

Howell-Jolly bodies

Answer 1

Hyposplenia

Question 2

Burr cells

Answer 2

Uremia

Question 3

Heinz bodies

Answer 3

G6PD deficiency

Question 4

Reticulocytes

Answer 4

Bleeding and haemolysis

Question 5

Target cells

Answer 5

Liver disease and IDAA

Question 6

CRAB

Answer 6

C = Calcium (elevated) – hypercalcemia

R = Renal failure: The most common cause of kidney failure in the myeloma patient is due to the proteins secreted by the malignant cells.

A = Anemia: Anemia caused by myeloma results from the replacement of normal bone marrow by infiltrating tumor cells and inhibition of normal red blood cell production.

B = Bone lesions (bone pain): Bone pain affects a majority of myeloma patients, usually in the spine and ribs. Bone fractures and spinal cord compression is also common. The breakdown of bone also leads to the release of calcium in the blood, leading to hypercalcemia. It is common for bone problems to cause pain, breaks, and spinal problems.

Question 7

Increase in HbF
skull bossing
Maxillary hypertrophy

Answer 7

Beta-Thalassemia

Question 8

Painless obstructive jaundice

Answer 8

Carcinoma of the head of the pancreas

Question 9

Painless total haematuria

Answer 9

Bladder carcinoma

Question 10

Reed-Sternberg cells

Answer 10

Hodgkin’s lymphoma

Question 11

Auer rods

Answer 11

Acute myeloid leukemia

Question 12

Middle age, increase increase WCC, Gout and Philadelphia chromosome

Answer 12

CML

Question 13

Bone pain 
Renal failure
Hyperviscioty- renal haemorrhages
Monoclonal Ig band on electrophoresis 
Bone marrow biopsy

Answer 13

Multiple myeloma