Haematology I Flashcards
What is the difference between plasma fluid and blood?
Blood is the main circulating fluid in the body
- PLASMA fluid is part of the blood that contain nutrients such as water, glucose, amino acids, proteins, hormones, vitamins, minerals, antibodies, and dissolved carbon dioxide.
What is the volume of BLOOD in the average adult?
5L
What type of tissue is blood?
Specialised connective tissue
What is BLOOD composed of?(4)
- Plasma
- RBC
- WBC
- Platelets
What is the percentage composition of each component of the blood?
- Plasma = 55%
- WBC and PLATELETS = <1%
- Red blood cells= 45%
What is each components of the plasma fluid composition?
- 92% water
- 7% protein
- 1% other solutes
What is ERYTHROPOIESIS?
Red blood cell formation
What is HAEMOPOIESIS?
its how blood cells are (just general)
What is Thrombocytes formed for?
Megakaryocytes
What does myoBLAST subdivide into?
- Basophils
- neutrophils
- eusonophils
- monocyte = Macrophages
Describe the formation of RBC in terms of HAEMATOPOIESIS?
1) Multipotent hemopoietic stem cell
2) Common MYELOID progenitor
3) Erythrocytes
4) RBC
What can the common MYELOID progenitor differentiate into?(4)
Megakaryocyte
Erythrocyte
Mast cell
MyoBLAST
Describe the the formation of plasm B cell in terms of HAEMTOPOIESIS process?
- Multipotent HEAMPOIETIC stem cell
- common LYMPHOID progenitor
- B cells
- Plasm B cells
Describe erythropoiesis?
- Hecmocytoblast/Multipotent Hemaoietic stem cell
- ProerythroBLAST
- EARLY eryhtroBLAST
- Late erythroBLAST
- NomoBLAST
- Reticucolocyte
- ERYthrocytes
What are the 3 phases that occur during the developmental cell?
- Ribosome synthesis
- Haemoglobin accumulation
- Ejection of nucleus
What is eryhtroPOIETIN?
growth factor, acts on precursor converting it to RBC
What are all the elements require for HAEMOGLOBIN (RBC)development?
- Iron
- Vitamin B12 & Folic acid
- intrinsic factor
- Amino acids
Where does eryhtoropoieSis occur in foetus?
early in yolk sac, then in liver & spleen and then in bone marrow at end of the pregnancy
Where does eryhtorpoieSis occur in infants/little kids?
Bone marrow
Where does erythropoieSis occur in Adults?
RED bone marrow only!
What is the lifespan of a RBC?
120 days
What happens when a red blood cells comes at the end of its life span?
it is Recycled
