Haematology disorders - Red cell and Clotting disorders Flashcards
Anemia
S/S
Red cell indices
Use of WBC and PLT count in anemia
Peripheral blood smear
Types of abnormal RBC
Ddx normocytic anemia
Howell Jolly bodies
Polychromasia
Basophilic stippling
Ddx target cells
Spherocytes
Red cell fragments
Ddx low RBC production
Ddx increased peripheral consumption of RBC
Ddx normocytic, microcytic, macrocytic anemia
Approach to microcytic anemia
Approach to macrocytic anemia
Microcytic anemia
Ddx
Mc Anemia
Ix
Iron metabolism
Absorption
Recycling
Storage
Iron deficiency
Causes
Progression of iron deficiency
IDA
S/S
IDA
Ix
IDA
Mx
Causes of refractory IDA
Thalassemia
Pathogenesis
A-thal
Pathogenesis
A thal
Clinical presentation in minima, minor, intermedia, major
B-thal
Pathogenesis
B-thal
Clinical presentation of minor, intermedia, major
Thalassemia
Anemic symptoms
Extremedullary hematopoiesis
Symptoms
Iron overload
Symptoms
Thalassemia
Cardiopulmonary complications
Thalassemia
Musculoskeletal complications
Thalassemia
Ix
Thalassemia
Mx
Thalassemia
Treatment for iron overload
Refractory to transfusion Mx
Thalassemia
Disease monitoring
Familial anemia
Ddx
Familial anemia
Hx
P/E
Aplastic anemia
Primary and secondary causes
Aplastic anemia
Pathogenesis
S/S
Aplastic anemia
Ix
Aplastic anemia
Severity grading
Prognosis
Aplastic anemia
Mx
Fanconi anemia
Cause
S/S
Dx
Mx
Prognosis