Haematology disorders - Red cell and Clotting disorders Flashcards

1
Q

Anemia

S/S

A
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2
Q

Red cell indices

A
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3
Q

Use of WBC and PLT count in anemia

A
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4
Q

Peripheral blood smear

Types of abnormal RBC

A
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5
Q

Ddx normocytic anemia
Howell Jolly bodies
Polychromasia
Basophilic stippling

A
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6
Q

Ddx target cells
Spherocytes
Red cell fragments

A
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7
Q

Ddx low RBC production

A
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8
Q

Ddx increased peripheral consumption of RBC

A
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9
Q

Ddx normocytic, microcytic, macrocytic anemia

A
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10
Q

Approach to microcytic anemia

A
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11
Q

Approach to macrocytic anemia

A
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12
Q

Microcytic anemia

Ddx

A
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13
Q

Mc Anemia

Ix

A
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14
Q

Iron metabolism

Absorption
Recycling
Storage

A
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15
Q

Iron deficiency

Causes

A
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16
Q

Progression of iron deficiency

A
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17
Q

IDA

S/S

A
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18
Q

IDA

Ix

A
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19
Q

IDA

Mx
Causes of refractory IDA

A
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20
Q

Thalassemia

Pathogenesis

A
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21
Q

A-thal

Pathogenesis

A
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22
Q

A thal

Clinical presentation in minima, minor, intermedia, major

A
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23
Q

B-thal

Pathogenesis

A
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24
Q

B-thal

Clinical presentation of minor, intermedia, major

A
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25
Q

Thalassemia

Anemic symptoms

A
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26
Q

Extremedullary hematopoiesis

Symptoms

A
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27
Q

Iron overload

Symptoms

A
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28
Q

Thalassemia

Cardiopulmonary complications

A
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29
Q

Thalassemia

Musculoskeletal complications

A
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30
Q

Thalassemia

Ix

A
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31
Q

Thalassemia

Mx

A
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32
Q

Thalassemia

Treatment for iron overload
Refractory to transfusion Mx

A
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33
Q

Thalassemia

Disease monitoring

A
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34
Q

Familial anemia

Ddx

A
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35
Q

Familial anemia

Hx
P/E

A
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36
Q

Aplastic anemia

Primary and secondary causes

A
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37
Q

Aplastic anemia

Pathogenesis
S/S

A
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38
Q

Aplastic anemia

Ix

A
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39
Q

Aplastic anemia

Severity grading
Prognosis

A
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40
Q

Aplastic anemia

Mx

A
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41
Q

Fanconi anemia

Cause
S/S
Dx
Mx
Prognosis

A
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42
Q

Dyskeratosis congenita

Cause
S/S
Dx
Mx
Prognosis

A
43
Q

Diamond blackfan anemia

Cause
S/S
Dx
Mx
Prognosis

A
44
Q

Ddx acquired hemolytic anemia

A
45
Q

Intravascular hemolysis

Causes
Pathogenesis
Clinical presentation

A
46
Q

Extravascular hemolysis

Causes
Pathogenesis
Clinical presentation

A
47
Q

Hemolytic anemia

Ix

A
48
Q

Red cell membrane

Proteins for cytoskeleton

A
49
Q

Hereditary spherocytosis

Pathogenesis
Clinical presentation

A
50
Q

Hereditary spherocytosis

Dx
Mx

A
51
Q

Pyruvate kinase deficiency

Cause
S/S
Dx
Mx

A
52
Q

G6PD

Pathogenesis

A
53
Q

G6PD

Clinical presentation

A
54
Q

G6PD

Triggers of hemolysis

A
55
Q

G6PD hemolysis

Ix
Mx

A
56
Q

Hemoglobin defects

Ddx

A
57
Q

Hemostasis

Physiology

A
58
Q

Coagluation cascade

A
59
Q

PT, aPTT function

A
60
Q

Clotting disorder

Vasculature causes

A
61
Q

Congenital platelet defects

A
62
Q

Acquired platelet defects

A
63
Q

Coagulation defects

A
64
Q

Differentiate platelet vs coagluation defect

A
65
Q

Clotting defect

Hx

A
66
Q

Clotting disorder

P/E

A
67
Q

Clotting disorder

Ix

A
68
Q

Thrombocytopenia

Ddx

A
69
Q

Thrombocytopenia

Ix

A
70
Q

Thrombocytopenia

Mx

A
71
Q

ITP

Causes

A
72
Q

ITP

Pathogenesis

A
73
Q

ITP

Clinical presentation

A
74
Q

ITP

Dx

A
75
Q

ITP

Mx
1st line therapy

A
76
Q

ITP

2nd line therapy/ Mx of refractory ITP

A
77
Q

Clotting profile

Metrics
Typical range

A
78
Q

Clotting Factor deficiency tests

A
79
Q

Ddx isolated prolonged PT, aPTT

A
80
Q

Ddx prolonged PT and aPTT
Ddx bleeding with normal clotting profile

A
81
Q

Approach to isolated prolonged PT/ aPTT

A
82
Q

Approach to prolonged PT + aPTT

A
83
Q

Hemophilia

Cause
Severity grading

A
84
Q

Hemophilia

Clinical presentation

A
85
Q

Hemophilia

Ix

A
86
Q

Hemophilia

Mx

A
87
Q

Hemophilia

Indications for prophylactic vs on-demand factor replacement

A
88
Q

Hemophilia

Specific tx for types of bleeding

A
89
Q

Hemophilia

Refractory to factor replacement
Mx

A
90
Q

VWD

Types
Pathogenesis

A
91
Q

VWD

S/S

A
92
Q

VWD

Ix
Dx

A
93
Q

VWD

Mx

A
94
Q

Thrombophilia

Ddx

A
95
Q

Antithrombin deficiency

Clinical features
Tx

A
96
Q

Protein C/S deficiency

Clinical presentation
Tx

A
97
Q

Workup for unexplained thrombosis

A
98
Q

DIC

Pathogenesis

A
99
Q

MAHA, TMA, DIC Definition

A
100
Q

DIC

Causes

A
101
Q

DIC
Clinical presentation
Cx

A
102
Q

DIC

A
103
Q

DIC

Ix

A
104
Q

DIC

Mx

A