Haematology disorders - Red cell and Clotting disorders

Question 1

Anemia

S/S

Answer 1

Question 2

Red cell indices

Answer 2

Question 3

Use of WBC and PLT count in anemia

Answer 3

Question 4

Peripheral blood smear

Types of abnormal RBC

Answer 4

Question 5

Ddx normocytic anemia
Howell Jolly bodies
Polychromasia
Basophilic stippling

Answer 5

Question 6

Ddx target cells
Spherocytes
Red cell fragments

Answer 6

Question 7

Ddx low RBC production

Answer 7

Question 8

Ddx increased peripheral consumption of RBC

Answer 8

Question 9

Ddx normocytic, microcytic, macrocytic anemia

Answer 9

Question 10

Approach to microcytic anemia

Answer 10

Question 11

Approach to macrocytic anemia

Answer 11

Question 12

Microcytic anemia

Ddx

Answer 12

Question 13

Mc Anemia

Ix

Answer 13

Question 14

Iron metabolism

Absorption
Recycling
Storage

Answer 14

Question 15

Iron deficiency

Causes

Answer 15

Question 16

Progression of iron deficiency

Answer 16

Question 17

IDA

S/S

Answer 17

Question 18

IDA

Ix

Answer 18

Question 19

IDA

Mx
Causes of refractory IDA

Answer 19

Question 20

Thalassemia

Pathogenesis

Answer 20

Question 21

A-thal

Pathogenesis

Answer 21

Question 22

A thal

Clinical presentation in minima, minor, intermedia, major

Answer 22

Question 23

B-thal

Pathogenesis

Answer 23

Question 24

B-thal

Clinical presentation of minor, intermedia, major

Answer 24

Question 25

Thalassemia

Anemic symptoms

Answer 25

Question 26

Extremedullary hematopoiesis

Symptoms

Answer 26

Question 27

Iron overload

Symptoms

Answer 27

Question 28

Thalassemia

Cardiopulmonary complications

Answer 28

Question 29

Thalassemia

Musculoskeletal complications

Answer 29

Question 30

Thalassemia

Ix

Answer 30

Question 31

Thalassemia

Mx

Answer 31

Question 32

Thalassemia

Treatment for iron overload
Refractory to transfusion Mx

Answer 32

Question 33

Thalassemia

Disease monitoring

Answer 33

Question 34

Familial anemia

Ddx

Answer 34

Question 35

Familial anemia

Hx
P/E

Answer 35

Question 36

Aplastic anemia

Primary and secondary causes

Answer 36

Question 37

Aplastic anemia

Pathogenesis
S/S

Answer 37

Question 38

Aplastic anemia

Ix

Answer 38

Question 39

Aplastic anemia

Severity grading
Prognosis

Answer 39

Question 40

Aplastic anemia

Mx

Answer 40

Question 41

Fanconi anemia

Cause
S/S
Dx
Mx
Prognosis

Answer 41

Question 42

Dyskeratosis congenita

Cause
S/S
Dx
Mx
Prognosis

Answer 42

Question 43

Diamond blackfan anemia

Cause
S/S
Dx
Mx
Prognosis

Answer 43

Question 44

Ddx acquired hemolytic anemia

Answer 44

Question 45

Intravascular hemolysis

Causes
Pathogenesis
Clinical presentation

Answer 45

Question 46

Extravascular hemolysis

Causes
Pathogenesis
Clinical presentation

Answer 46

Question 47

Hemolytic anemia

Ix

Answer 47

Question 48

Red cell membrane

Proteins for cytoskeleton

Answer 48

Question 49

Hereditary spherocytosis

Pathogenesis
Clinical presentation

Answer 49

Question 50

Hereditary spherocytosis

Dx
Mx

Answer 50

Question 51

Pyruvate kinase deficiency

Cause
S/S
Dx
Mx

Answer 51

Question 52

G6PD

Pathogenesis

Answer 52

Question 53

G6PD

Clinical presentation

Answer 53

Question 54

G6PD

Triggers of hemolysis

Answer 54

Question 55

G6PD hemolysis

Ix
Mx

Answer 55

Question 56

Hemoglobin defects

Ddx

Answer 56

Question 57

Hemostasis

Physiology

Answer 57

Question 58

Coagluation cascade

Answer 58

Question 59

PT, aPTT function

Answer 59

Question 60

Clotting disorder

Vasculature causes

Answer 60

Question 61

Congenital platelet defects

Answer 61

Question 62

Acquired platelet defects

Answer 62

Question 63

Coagulation defects

Answer 63

Question 64

Differentiate platelet vs coagluation defect

Answer 64

Question 65

Clotting defect

Hx

Answer 65

Question 66

Clotting disorder

P/E

Answer 66

Question 67

Clotting disorder

Ix

Answer 67

Question 68

Thrombocytopenia

Ddx

Answer 68

Question 69

Thrombocytopenia

Ix

Answer 69

Question 70

Thrombocytopenia

Mx

Answer 70

Question 71

ITP

Causes

Answer 71

Question 72

ITP

Pathogenesis

Answer 72

Question 73

ITP

Clinical presentation

Answer 73

Question 74

ITP

Dx

Answer 74

Question 75

ITP

Mx
1st line therapy

Answer 75

Question 76

ITP

2nd line therapy/ Mx of refractory ITP

Answer 76

Question 77

Clotting profile

Metrics
Typical range

Answer 77

Question 78

Clotting Factor deficiency tests

Answer 78

Question 79

Ddx isolated prolonged PT, aPTT

Answer 79

Question 80

Ddx prolonged PT and aPTT
Ddx bleeding with normal clotting profile

Answer 80

Question 81

Approach to isolated prolonged PT/ aPTT

Answer 81

Question 82

Approach to prolonged PT + aPTT

Answer 82

Question 83

Hemophilia

Cause
Severity grading

Answer 83

Question 84

Hemophilia

Clinical presentation

Answer 84

Question 85

Hemophilia

Ix

Answer 85

Question 86

Hemophilia

Mx

Answer 86

Question 87

Hemophilia

Indications for prophylactic vs on-demand factor replacement

Answer 87

Question 88

Hemophilia

Specific tx for types of bleeding

Answer 88

Question 89

Hemophilia

Refractory to factor replacement
Mx

Answer 89

Question 90

VWD

Types
Pathogenesis

Answer 90

Question 91

VWD

S/S

Answer 91

Question 92

VWD

Ix
Dx

Answer 92

Question 93

VWD

Mx

Answer 93

Question 94

Thrombophilia

Ddx

Answer 94

Question 95

Antithrombin deficiency

Clinical features
Tx

Answer 95

Question 96

Protein C/S deficiency

Clinical presentation
Tx

Answer 96

Question 97

Workup for unexplained thrombosis

Answer 97

Question 98

DIC

Pathogenesis

Answer 98

Question 99

MAHA, TMA, DIC Definition

Answer 99

Question 100

DIC

Causes

Answer 100

Question 101

DIC
Clinical presentation
Cx

Answer 101

Question 102

DIC

Answer 102

Question 103

DIC

Ix

Answer 103

Question 104

DIC

Mx

Answer 104