Haem 17: Interactive Cases Flashcards
what condition do the following suggest:
- mediastinal mass
- no platelets
- blast cells
- high WCC
T lineage ALL - thymoma
= ALL of T lineage
immunophenotyping important
high WCC is a BAD prognostic feature
needs combination chemo and CNS-directed therapy
what condition does the following suggest:
- 2 weeks bleeding gums
- haematuria
- minor bruising
- L subconjunctival haemorrhage
- no hepatosplenomegaly or enlarged LN
- normal renal fn
- granuels and Auer rods
granules and auer rods = myeloid
granular cells = acute promyelocytic leukaemia
confirm by cytogenetic analysis/ FISH/ molecular genetic analysis
15;17 translocation forming the PML-RARA fusion gene
tx - platelets, chemo, ATRA
can cause short APTT - activation of coagulation factors accelerated clotting of the plasma
what condition does the following suggest:
- gradual onset fatigue, lethargy, exertional dyspnoea
- pallor
- mild ankle oedema
- low Hb
- high MCV
- low neutrophils
- high platelets
- hypochromic macrocytes
diamorphic film
MDS
what condition does the following suggest:
- vegetarian
- SOBOE
- fatigue
- cant eat spicy food
- pallor
- WBC normal
- Hb low
- MCV high
- n platelets
- patietal Ab positive
- IF Ab positive
- low B12
megaloblastic anaemia due to pernicious anaemia
what condition do the following suggest:
- gangrenous toes
- SOBOE
- reduced femoral and distal pulses
- plethora
PV
JAK mutation investigation
Tx = venesection + hydroxycarbamide
