GYN Oncology, Breast Flashcards

1
Q

What are the categories of benign breast lesions?

A
  1. Nonproliferative
  2. Proliferative
  3. Atypical hyperplasia
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2
Q

What is an example of a nonproliferative benign breast lesion?

A

Breast cyst

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3
Q

What is an example of a proliferative benign breast lesion?

A

Fibroadenoma
Intraductal papilloma

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4
Q

What is an example of atypical hyperplasia benign breast lesion?

A

Atypical ductal hyperplasia
Atypical lobular hyperplasia

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5
Q

What is a breast cyst?

A

benign fluid filled sac in the breast

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6
Q

What is a fibroadenoma?

A

Benign tumor of the breast composed of glandular and stromal connective tissue

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7
Q

What is a intraductal papilloma?

A

Benign breast lesion that consists of wart like lump that develops in 1 or more milk ducts

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8
Q

What is atypical ductal hyperplasia?

A

Atypical ductal hyperplasia is a premalignant proliferative breast lesion with high risk of ductal carcinoma in situ or invasive breast cancer

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9
Q

What is atypical lobular hyperplasia?

A

Atypical lobular hyperplasia is a premalignant proliferative breast lesion with high risk invasive breast cancer

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10
Q

What is BIRADS category 0?

A

Incomplete, additional testing needed

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11
Q

What is BIRADS category 1?

A

Negative, 0% likelihood of cancer, routine imaging

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12
Q

What is BIRADS category 2?

A

Benign, 0% likelihood of cancer, routine imaging

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13
Q

What is BIRADS category 3?

A

Probably benign, 0-2% likelihood of cancer, 6 month follow up

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14
Q

What is BIRADS category 4?

A

Suspicious
4A= low, >0%<10%
4B= >10%<50%
4C= >50%<95%
Tissue diagnosis

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15
Q

What is BIRADS category 5?

A

Highly suggestive of malignancy
>95% likelihood of cancer
Tissue diagnosis

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16
Q

What is the lifetime risk of breast cancer?

A

12%

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17
Q

Are breast self exams recommended?

A

Not in average risk women due to risk of false positives

18
Q

What is the breast screening protocol by ACOG?

A

Screening from age 40-75 either annual or biennial
Clinical breast exam >40y/o

19
Q

What is the breast screening protocol by American Cancer Society?

A

Annual screening from 40-54
Biennial screening 55- until 10 years before anticipate death
Clinical breast exam not recommended

20
Q

What should you known about women with dense breast?

A

Mammogram less sensitive
Dense breast confer increased cancer risk

21
Q

What is lobular carcinoma a marker for?

A

Future malignancy

22
Q

How do you determine what imaging to perform for the workup of a breast mass?

A

<30y/o= ultrasound
>30y/o = mammogram

23
Q

When is it appropriate to aspirate a breast mass?

A

Only if its cystic

24
Q

When should you do an excision or biopsy for a breast mass?

A
  1. Suspicious solid palpable breast mass
  2. Non-palpable suspicious mammogram finding
  3. Aspiration with bloody fluid or mass that fails to resolve
  4. Mass associated with bloody nipple discharge or ulceration
25
Q

What is the management for atypical hyperplasia/lobular carcinoma in situ?

A

Mammogram annually if over 30
Clinical breast exam q6-12 months
Breast self awareness
Risk reduction recommended with tamoxifen

26
Q

In a patient with nipple discharge, when should you be concerned for underlying pathology?

A

Spontaneous discharge
Persistent discharge
Expressed on exam
single duct
Clear/serous or bloody

27
Q

What kind of symptoms do you see with inflammatory breast cancer?

A

Skin thickening
Edema
peau dā€™ orange
persistent erythema
nipple excoriations
skin ulcerations

28
Q

What is positive receptor status in breast cancer associated with?

A

Better response to hormonal therapy
Tumors more often well differentiated and slower growing

29
Q

What are the adjuvant therapies for breast cancer?

A
  1. Tamoxifen
  2. Raloxifene
  3. Aromatase inhibitors
  4. Herceptin
30
Q

What kind of Breast cancer patients can you use tamoxifen in?

A

ER+/Unknown
Pre or post menopausal

31
Q

What kind of Breast cancer patients can you use raloxifene in?

A

ER+
Postmenopausal

32
Q

What kind of Breast cancer patients can you use aromatase inhibitors in?

A

ER+/Unknown
Postmenopausal

33
Q

What kind of Breast cancer patients can you use Herceptin in?

A

Her2/Neu+
Pre or post menopausal

34
Q

What is the risk of tamoxifen therapy?

A

VTE

35
Q

What is the risk of raloxifene therapy?

A

VTE

36
Q

What is the risk of aromatase inhibitor therapy?

A

Bone loss

37
Q

What is the most common cause of bloody nipple discharge?

A

Benign intraductal papilloma

38
Q

What is the most common cause for a solid breast mass?

A

Fibroadenoma

39
Q

What is Paget disease of the breast associated with?

A

Underlying intraductal or invasive carcinoma of the breast

40
Q

When is breast MRI indicated?

A
  1. BRCA 1,2 mutation
  2. First degree relative of BRCA 1,2
  3. Lifetime risk of breast cancer is >20%
  4. Chest radiation between 10-30y/o