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STEP1: MSK > Gout drugs > Flashcards

Gout drugs Flashcards

1
Q

Allopurinol

A

Inhibit XO (converts xanathine to uric acid)

Increase concentration of azathioprine and 6MP
Do not give salicylate: all but the highest doses depress uric acid clearnace.

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2
Q

Febuxostat

A

XO inhibitor

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3
Q

Probenecid

A

Inhibit reabsorption of uric acid in PCT

also inhibit secretion of penicillin

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4
Q

Low dose salicylate

and diuretics

A

Block tubular secretion of uric acid

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5
Q

High dose salicylate

and probenecid

A

Inhibit tubular reabsorption.

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STEP1: MSK (31 decks)

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